ZFP442 Inhibitors
Chemical inhibitors of ZFP442 can act through different molecular mechanisms to inhibit its activity. PD 98059 and U0126 are both inhibitors of MEK, a kinase that acts upstream of ERK in the MAPK signaling pathway. When MEK is inhibited by these chemicals, the subsequent activation of ERK is also inhibited, which in turn can lead to a reduction in the phosphorylation and activity of ZFP442. Similarly, SL327 targets MEK1/2 to inhibit the ERK pathway and thus can inhibit the activation of ZFP442. SB203580 operates through a different mechanism, targeting p38 MAPK, another kinase that can influence the function of ZFP442. By inhibiting p38 MAPK, SB203580 can decrease the activation of ZFP442 that is dependent on the p38 MAPK signaling pathway.
LY294002 and Wortmannin are inhibitors of PI3K, which plays a crucial role in the PI3K/Akt pathway that modulates ZFP442 activity. By inhibiting PI3K, these chemicals can reduce Akt phosphorylation and activity, leading to a decrease in ZFP442 activity. Rapamycin, an inhibitor of mTOR, can also suppress the activity of ZFP442 by inhibiting a pathway that is critical for cell growth and survival and which can regulate proteins like ZFP442. Y-27632, a ROCK inhibitor, disrupts the actin cytoskeleton dynamics, which can affect the localization and function of ZFP442, leading to its inhibition. PP2 and Dasatinib are both inhibitors of Src family kinases, which are involved in multiple signaling pathways that can regulate ZFP442. Inhibition of these kinases by PP2 or Dasatinib can lead to a decrease in the activation and function of ZFP442. Finally, BAY 11-7082 inhibits NF-κB activation, which can regulate the expression and activity of various proteins, including ZFP442. By preventing NF-κB activation, BAY 11-7082 can reduce the activity of ZFP442 that is dependent on NF-κB signaling.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a selective inhibitor of MEK, which is upstream of ERK in the MAPK signaling pathway. ZFP442 is known to be regulated by this pathway; thus, inhibition of MEK by PD 98059 would lead to decreased ERK activity, which in turn could inhibit the phosphorylation and activity of ZFP442. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K. ZFP442 activity is modulated by the PI3K/Akt pathway. By inhibiting PI3K, LY294002 can reduce Akt phosphorylation and activity, which is necessary for the full activation of ZFP442, resulting in its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, a kinase involved in the regulation of transcription factors. As JNK can influence the activity of proteins like ZFP442, its inhibition can prevent the activation of ZFP442 that depends on JNK-mediated signaling pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor, and ROCK is implicated in controlling actin cytoskeleton dynamics. Since the localization and function of ZFP442 may be dependent on cytoskeletal structures, Y-27632 can disrupt these and inhibit ZFP442's functional capacity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, which can regulate transcription factors and proteins such as ZFP442. Inhibition of p38 MAPK by SB203580 would result in decreased activation of ZFP442 that is p38 MAPK dependent. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. mTOR is part of the cellular growth and survival pathway, which can regulate proteins like ZFP442. Inhibition of mTOR by Rapamycin can lead to reduced activity of ZFP442 that is mTOR pathway-dependent. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor like LY294002, and it functions in a similar manner. By inhibiting PI3K, Wortmannin leads to decreased Akt activity, thereby inhibiting the activity of downstream proteins such as ZFP442. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of Src family kinases, which are involved in various signaling pathways that can regulate proteins like ZFP442. Inhibition of these kinases by PP2 can inhibit the activation and function of ZFP442. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, similar to PD 98059. By inhibiting MEK1/2, U0126 prevents the activation of ERK, a kinase that can regulate the activity of ZFP442, leading to its functional inhibition. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor, which includes Src family kinases. By inhibiting these kinases, Dasatinib can block signaling pathways that are necessary for the activation and function of ZFP442. | ||||||