ZFF29 Activators
Chemical activators of ZFF29 can initiate a cascade of intracellular events leading to the phosphorylation and subsequent activation of the protein. Forskolin, by elevating intracellular cyclic AMP (cAMP) levels through direct activation of adenylate cyclase, can facilitate the activation of protein kinase A (PKA). The activated PKA can then phosphorylate ZFF29, enhancing its activity. Similarly, isoproterenol, which targets beta-adrenergic receptors, also stimulates adenylate cyclase, augmenting cAMP levels, and subsequently activating PKA, which in turn can phosphorylate ZFF29. Additionally, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate ZFF29, influencing its activity. Ionomycin, a calcium ionophore, can increase intracellular calcium concentrations, which may activate calmodulin-dependent kinase (CaMK). CaMK, upon activation, can phosphorylate ZFF29 either directly or through other associated signaling pathways.
Continuing with the activation mechanisms, insulin can trigger the PI3K/Akt signaling pathway, which has several downstream effects, including the phosphorylation of various proteins. Within this pathway, Akt can facilitate the phosphorylation and activation of ZFF29. The Epidermal Growth Factor (EGF) engages its receptor to initiate the MAPK/ERK signaling cascade, which can also lead to the phosphorylation of ZFF29. Glutamate, through its receptors, can activate CaMK or PKC, both of which can phosphorylate and activate ZFF29. Histamine can bind to G-protein-coupled receptors to activate phospholipase C, which increases the production of diacylglycerol (DAG) and inositol trisphosphate (IP3). This increase can result in PKC activation, and PKC can then phosphorylate ZFF29. Furthermore, hydrogen peroxide can modulate various kinases and phosphatases, potentially leading to the activation of ZFF29 through oxidative signaling pathways. Nitric Oxide Donors, like SNAP, release nitric oxide that can activate guanylate cyclase, increasing cyclic GMP (cGMP) levels. cGMP-dependent kinases can then phosphorylate ZFF29. Anisomycin activates stress-activated protein kinases such as JNK, which can phosphorylate ZFF29. Lastly, ouabain inhibits the Na+/K+ ATPase pump, causing an increase in intracellular sodium and calcium, which can activate CaMK and PKC, leading to the phosphorylation of ZFF29.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels within the cell. Elevated cAMP can activate protein kinase A (PKA), which in turn can phosphorylate ZFF29, enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as an ionophore for calcium, increasing intracellular calcium concentrations. Calcium can activate calmodulin-dependent kinase (CaMK), which may phosphorylate and thereby activate ZFF29 directly or through downstream signaling cascades that ZFF29 is a part of. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). PKC can phosphorylate ZFF29 or signaling intermediates in pathways involving ZFF29, leading to its activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol activates beta-adrenergic receptors, which stimulate adenylate cyclase to increase cAMP levels. cAMP activates PKA, which can phosphorylate and activate ZFF29. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin can activate the PI3K/Akt signaling pathway, which is involved in the phosphorylation and activation of many proteins. Akt can directly or indirectly lead to the phosphorylation and activation of ZFF29 through downstream signaling mechanisms within its pathway. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamate acts on its receptors, which can lead to the activation of intracellular signaling pathways such as CaMK or PKC, both of which could phosphorylate and activate ZFF29. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can bind to its G-protein-coupled receptors (GPCRs), which can activate phospholipase C (PLC). PLC increases the production of diacylglycerol (DAG) and inositol trisphosphate (IP3), leading to PKC activation. PKC can then phosphorylate and activate ZFF29. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide can act as a signaling molecule, modulating the activity of various kinases and phosphatases. This can lead to the oxidative modification and activation of signaling pathways that include ZFF29, resulting in its functional activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases, like JNK. Activation of JNK can lead to the phosphorylation of ZFF29 or other proteins in pathways involving ZFF29, resulting in its activation. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain inhibits the Na+/K+ ATPase pump, leading to increased intracellular sodium and secondarily increased calcium through the Na+/Ca2+ exchanger. Elevated intracellular calcium can activate pathways that include CaMK and PKC, which may then phosphorylate and activate ZFF29. | ||||||