ZASC1 Inhibitors
ZASC1 Inhibitors are a group of chemical compounds that primarily target the DNA damage response pathway and the PI3K/Akt signaling pathway, both of which ZASC1 is directly involved in. Inhibitors that disrupt the structure and function of the Golgi apparatus, such as Brefeldin A, or inhibit the transport of vesicles to the plasma membrane, such as Exo2, can impede the trafficking of ZASC1 to the nucleus, thereby leading to its functional inhibition. Similarly, topoisomerase II inhibitors, such as Mitoxantrone and Etoposide, cause DNA damage, thereby overactivating the DNA damage response pathway in which ZASC1 is involved. This overactivation can disrupt ZASC1's role in DNA repair, leading to its functional inhibition.
On the other hand, tyrosine kinase inhibitors such as Genistein and Staurosporine can interfere with phosphorylation processes necessary for ZASC1's function, thereby leading to its functional inhibition. Inhibitors of PI3K and mTOR, such as LY294002, Wortmannin, and Rapamycin, can indirectly affect ZASC1's function in DNA repairand homologous recombination by modulating the PI3K/Akt pathway. Similarly, the phospholipase C inhibitor U73122, by influencing intracellular signaling, can indirectly impact the functional activity of ZASC1. Pervanadate, an inhibitor of protein tyrosine phosphatases, can affect the regulatory function of phosphoproteins, thereby influencing the functional activity of ZASC1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus, which might impede the trafficking of ZASC1 to the nucleus, leading to the decreased functional activity of ZASC1 in mediating DNA repair and homologous recombination. | ||||||
Exo2 | 304684-77-3 | sc-215011 sc-215011A | 5 mg 25 mg | $87.00 $282.00 | 1 | |
Exo2 is an inhibitor of the exocyst complex, which is involved in the transport of vesicles to the plasma membrane. It can indirectly inhibit the functional activity of ZASC1 by reducing the function of this pathway and thus impeding ZASC1's transport to the nucleus. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone is a topoisomerase II inhibitor. The DNA damage caused by Mitoxantrone can overactivate the DNA damage response pathway in which ZASC1 participates, potentially disrupting ZASC1's role in DNA repair. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that triggers the DNA damage response pathway, an essential pathway in which ZASC1 is involved. Overactivation of this pathway can disrupt ZASC1's role in DNA repair. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can interfere with phosphorylation processes necessary for ZASC1's function in DNA repair and homologous recombination, thereby leading to its functional inhibition. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. It can interfere with phosphorylation processes essential for ZASC1's function in DNA repair and homologous recombination, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, a key enzyme in the PI3K/Akt pathway. By inhibiting PI3K, it can indirectly affect ZASC1’s function in DNA repair and homologous recombination. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key protein in the PI3K/Akt pathway. By inhibiting mTOR, it can indirectly affect ZASC1’s function in DNA repair and homologous recombination. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent, irreversible inhibitor of PI3K, a key enzyme in the PI3K/Akt pathway. It can indirectly inhibit ZASC1, which is involved in DNA repair and homologous recombination. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein biosynthesis in eukaryotic organisms. While it does not inhibit transcription or translation of ZASC1, it can indirectly affect the replenishment of ZASC1 levels, thus affecting its function in DNA repair and homologous recombination. | ||||||