YY1 Inhibitors
YY1, also known as Yin Yang 1, is a ubiquitously expressed transcription factor with diverse roles in numerous cellular processes, including embryogenesis, differentiation, replication, and apoptosis. It possesses dual regulatory functions, acting as both an activator and a repressor of gene transcription. Given its multifaceted nature, YY1 can bind to an array of DNA target sequences and interact with a multitude of other proteins, thereby regulating a vast number of genes. The name Yin Yang reflects its dual nature in gene regulation, underscoring its ability to either upregulate or downregulate the expression of target genes. The structure of YY1 comprises four C2H2-type zinc fingers, which facilitate DNA binding, and other domains that allow protein-protein interactions.
YY1 inhibitors are chemical entities specifically designed to modulate the activity of the YY1 transcription factor. By targeting YY1, these inhibitors can influence the transcriptional activity of numerous genes that YY1 regulates. The mechanisms of action of these inhibitors can vary: some might interfere with the DNA-binding capability of YY1 by altering its conformation, while others might prevent its interaction with co-regulatory proteins, thus affecting its transcriptional activity.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to DNA and interferes with DNA-protein interactions. By binding to DNA, it inhibits YY1's ability to bind DNA and regulate gene expression. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole) is a transcription inhibitor that suppresses the function of transcription factors, including YY1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin-3-gallate, a major component of green tea, down-regulates the expression of YY1. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
Caffeic acid phenethyl ester, a compound from bee propolis, inhibits YY1's binding to target gene promoters by altering its expression. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin is a polysulfonated naphthylurea that inhibits various growth factors. It down-regulates YY1 by interfering with its DNA-binding activity. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $136.00 $492.00 | 13 | |
Garcinol inhibits histone acetyltransferases, which impacts YY1's modulation of gene expression, as YY1 is known to interact with these enzymes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural compound found in turmeric, down-regulates the expression of YY1 and its DNA-binding activity. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid suppresses YY1 expression, thereby affecting its regulatory role in various cellular processes. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid, a naturally occurring compound in certain fruits, down-regulates YY1 expression, impacting its role in transcriptional regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a common flavonoid found in many plants, reduces YY1's DNA-binding activity, which affects its regulatory function on target genes. | ||||||