YIF1A Inhibitors
Chemical inhibitors of YIF1A can interfere with its role in vesicular trafficking by targeting various molecules and processes that are crucial for the proper functioning of this protein. Alsterpaullone, as a cyclin-dependent kinase inhibitor, can arrest cell cycle progression, which is essential for the regulation of vesicular trafficking involving the Golgi apparatus. Since YIF1A is associated with the regulation of transport between the Golgi and the endoplasmic reticulum (ER), the disruption of cell cycle events by Alsterpaullone can indirectly lead to the inhibition of YIF1A function. Similarly, Brefeldin A, which inhibits ADP-ribosylation factor, can disrupt the formation of vesicles at the Golgi complex, consequently affecting the vesicular trafficking functions of YIF1A. ML-141, by selectively inhibiting Cdc42 GTPase, could interfere with the regulation of trafficking pathways that YIF1A is involved in, thus hindering its function.
Furthermore, Exo1 disrupts the exocyst complex responsible for vesicle tethering to the plasma membrane, which could indirectly affect YIF1A's role in vesicle docking and fusion. Dynasore inhibits dynamin, a GTPase essential for vesicle scission from the Golgi complex, potentially impeding YIF1A-related vesicle formation and release. Ilimaquinone disrupts the Golgi apparatus by affecting the microtubule network, which is also a critical component of the vesicular transport processes involving YIF1A. Latrunculin B's binding to actin monomers prevents their polymerization, crucial for the cytoskeletal dynamics that facilitate vesicular trafficking, thereby indirectly inhibiting YIF1A function. Golgicide A targets the Golgi-associated BFA-resistant guanine nucleotide exchange factor 1, which is involved in ARF-mediated vesicle formation, and its inhibition can disrupt processes where YIF1A is active. SecinH3 selectively inhibits cytohesins, leading to altered ARF GTPase activity and hence affecting YIF1A's role. Jasplakinolide disrupts actin dynamics by stabilizing actin filaments, which could impede the vesicular transport machinery, consequently affecting YIF1A function. Lastly, nocodazole disrupts microtubule polymerization, thereby potentially inhibiting the transport of vesicles involving YIF1A. Tyrphostin AG 879's inhibition of receptor tyrosine kinases can alter intracellular signaling related to vesicular trafficking, which can indirectly inhibit YIF1A's function in vesicle transport.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that can inhibit the cell cycle progression, which is a pathway where YIF1A is involved in the regulation of vesicular trafficking related to the Golgi apparatus. By inhibiting CDKs, Alsterpaullone may indirectly inhibit YIF1A by disrupting the cell cycle events that YIF1A is potentially associated with. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits ADP-ribosylation factor (ARF), a small GTPase involved in vesicle formation at the Golgi complex. Since YIF1A is implicated in Golgi to ER retrograde transport, the inhibition of ARF by Brefeldin A can disrupt the vesicular trafficking processes necessary for YIF1A function. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML-141 is a selective inhibitor of Cdc42 GTPase. YIF1A is involved in trafficking between the ER and Golgi, a process that requires precise regulation by small GTPases like Cdc42. Inhibition by ML-141 could hinder the trafficking pathway, indirectly inhibiting YIF1A function. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $84.00 $297.00 | 4 | |
Exo1 is an inhibitor of the exocyst complex, which is involved in the tethering of transport vesicles to the plasma membrane. YIF1A's role in vesicle transport suggests that inhibition of the exocyst could indirectly inhibit the vesicle docking and fusion processes involving YIF1A. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that targets dynamin, which is crucial for vesicle scission from the Golgi complex. As YIF1A operates in the Golgi to ER trafficking, dynasore can indirectly inhibit the function of YIF1A by preventing proper vesicle formation and release. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $240.00 | 29 | |
Latrunculin B binds to actin monomers and prevents polymerization, which is critical for cytoskeletal dynamics involved in vesicular trafficking. As YIF1A is engaged in vesicle transport, the inhibition of actin polymerization can indirectly inhibit YIF1A's function in trafficking. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Golgicide A is an inhibitor of the Golgi BFA-resistant guanine nucleotide exchange factor 1 (GBF1). As YIF1A is implicated in vesicular trafficking from the Golgi, inhibition of GBF1 by Golgicide A can indirectly inhibit YIF1A by disrupting ARF-mediated vesicle formation. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 selectively inhibits cytohesins, which are ARF GTPase exchange factors. The inhibition of cytohesins can lead to altered ARF GTPase activity and thus potentially inhibit vesicular trafficking processes where YIF1A is implicated. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments and prevents their disassembly. This disruption of actin dynamics can impede vesicular transport machinery and pathways, indirectly inhibiting YIF1A's role in vesicle formation and trafficking. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which is essential for vesicular transport between the Golgi and ER. The disruption of microtubules by nocodazole can indirectly inhibit YIF1A by impeding the transport of vesicles in which YIF1A is involved. | ||||||