XPLN Activators
Chemicals classified as XPLN activators encompass a diverse array of molecules that can indirectly influence the activity of XPLN by modulating pathways and processes related to Rho GTPase signaling. The activity of Rho GTPases, the direct targets of XPLN's GEF activity, is tightly regulated by numerous factors including their phosphorylation status, their interaction with the actin cytoskeleton, and the activity of downstream signaling components.
Some chemicals such as PMA, Calyculin A, and Okadaic acid can potentially modulate the activity of XPLN by affecting the phosphorylation status of proteins involved in Rho GTPase regulation. Others, namely Jasplakinolide, Latrunculin A, and Cytochalasin D, indirectly influence XPLN activity by affecting the state of the actin cytoskeleton, a key element in Rho GTPase signaling. Lastly, molecules such as Y-27632, Fasudil, H1152, NSC23766, EHT 1864, and ZCL278 can indirectly modulate the GEF activity of XPLN by inhibiting Rho GTPases themselves or their downstream effectors, thereby changing the overall dynamics of Rho GTPase signaling.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC), which can phosphorylate various proteins involved in the regulation of GTPases and, in turn, indirectly modulate the GEF activity of XPLN. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a protein phosphatase inhibitor and can modulate XPLN activity by altering the phosphorylation status of proteins involved in GTPase regulation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a protein phosphatase inhibitor that can modulate XPLN activity by changing the phosphorylation status of proteins involved in GTPase regulation. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments, which are involved in Rho GTPase signaling, thereby indirectly influencing the GEF activity of XPLN. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts actin filaments and can indirectly influence XPLN activity by modulating the cellular processes that involve Rho GTPase signaling. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filaments and can indirectly influence XPLN activity by modulating the cellular processes that involve Rho GTPase signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor that can indirectly affect the GEF activity of XPLN by altering the downstream signaling of Rho GTPases. | ||||||
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $33.00 $87.00 $168.00 $253.00 $496.00 $910.00 | 5 | |
Fasudil is a ROCK inhibitor that can indirectly affect the GEF activity of XPLN by altering the downstream signaling of Rho GTPases. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H1152 is a ROCK inhibitor that can indirectly affect the GEF activity of XPLN by altering the downstream signaling of Rho GTPases. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT 1864 is a Rac1 GTPase inhibitor, which can indirectly modulate XPLN activity by changing the dynamics of Rho GTPase signaling. | ||||||