WIPI-4 Activators
WIPI-4 activators consist of a diverse array of chemical compounds that facilitate the protein's involvement in autophagosome formation, a critical process for cellular homeostasis. For instance, Phosphatidylinositol 3-phosphate, by providing a docking site on early endosomes, directly recruits WIPI-4, which is essential for autophagosome biogenesis. Similarly, Rapamycin, an mTOR inhibitor, triggers a cascade of events leading to the autophagy-mediated activation of WIPI-4. Spermidine and Nicotinamide both engage in the modulation of acetylation processes that ultimately result in the upregulation of autophagy and the enhanced role of WIPI-4. Trehalose and Resveratrol activate AMPK, which suppresses mTOR, a key negative regulator of autophagy, thus facilitating WIPI-4's action in autophagosome assembly. Lithium and Carbamazepine, through GSK-3 inhibition and inositol synthesis inhibition respectively, contribute to the induction of autophagy, promoting the function of WIPI-4 in this vital cellular recycling process.
Moreover, compounds such as Salicylate and Verapamil, though through different mechanisms, culminate in the induction of autophagy, leading to the indirect activation of WIPI-4. Salicylate achieves this by inhibiting mTOR acetylation, while Verapamil blocks calcium channels, both resulting in an environment conducive to WIPI-4's role in autophagy. Metformin, a widely known AMPK activator, suppresses mTOR signaling, thereby facilitating the autophagic process and, by extension, the function of WIPI-4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that initiates autophagy by inhibiting the mTOR pathway, which in turn indirectly activates WIPI-4 as part of the autophagic machinery. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is a natural polyamine that can induce autophagy by inhibiting the acetyltransferase EP300, which leads to the deacetylation and activation of autophagy-related proteins, including WIPI-4. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium acts as a glycogen synthase kinase 3 (GSK-3) inhibitor. GSK-3 inhibition has been shown to induce autophagy, thereby enhancing the functional activity of WIPI-4 in autophagosome formation. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, as an inhibitor of the sirtuin family of proteins, leads to increased acetylation levels of autophagy-related proteins, which can result in the activation of WIPI-4's role in autophagosome assembly. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $29.00 $164.00 $255.00 | 2 | |
Trehalose induces autophagy via the AMPK pathway, which leads to the suppression of mTOR, thereby indirectly activating WIPI-4. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates AMPK, which in turn inhibits mTOR signaling and promotes autophagy. This AMPK activation cascade enhances the recruitment and function of WIPI-4 in autophagosome formation. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $32.00 $70.00 | 5 | |
Carbamazepine induces autophagy by inhibiting inositol synthesis, thus indirectly enhancing the functional activity of WIPI-4, which is essential for the autophagosome membrane expansion and closure. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylate can induce autophagy by inhibiting mTOR acetylation and activity. This inhibition indirectly activates WIPI-4 and its role in autophagosome formation. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, is known to induce autophagy. This action may indirectly enhance WIPI-4 activity as it is an essential component of the autophagy machinery. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin activates AMPK, which leads to the inhibition of mTOR signaling and subsequent induction of autophagy. This process enhances the functionality of WIPI-4 in the autophagic pathway. | ||||||