WIP Activators
WIP (Wiskott-Aldrich syndrome protein-interacting protein) plays a significant role in the regulation of the actin cytoskeleton, influencing cellular processes such as migration, adhesion, and signal transduction. Given the lack of direct chemical activators, focus is shifted to compounds that modulate the actin cytoskeleton and related cellular processes. The chemicals listed above target various components of the cytoskeletal network and related signaling pathways, potentially influencing WIP activity. Actin dynamics modulators like Jasplakinolide, Cytochalasin D, Latrunculin A, Phalloidin, and Swinholide A directly affect the state of actin filaments, thereby potentially impacting WIP's function in actin organization. Inhibitors of proteins that interact with actin, such as Blebbistatin (myosin II inhibitor), CK-666 (Arp2/3 complex inhibitor), and ML-7 (myosin light chain kinase inhibitor), offer indirect routes to affect WIP activity.
Moreover, compounds like Y-27632, a ROCK inhibitor, and Forskolin, which increases cAMP levels, could influence signaling pathways relevant to WIP and actin dynamics. PI3K inhibitors like Wortmannin may also indirectly impact WIP activity by altering cell signaling pathways involved in cytoskeletal regulation. Nocodazole, a microtubule dynamics disruptor, highlights the intricate interplay between different components of the cytoskeleton, potentially affecting WIP's role in coordinating actin and microtubule interactions.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
A cyclodepsipeptide that stabilizes actin filaments, potentially influencing WIP activity in actin dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Disrupts actin microfilaments by sequestering actin monomers, potentially impacting WIP-associated pathways. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Stabilizes actin filaments, and its effects on the cytoskeleton could indirectly influence WIP activity. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
A dimeric macrolide that disrupts actin filaments, potentially affecting WIP's interaction with actin. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor, may impact actin cytoskeleton dynamics and thus indirectly affect WIP. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II, which may indirectly affect WIP's role in actin-myosin interactions and cellular mechanics. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
An Arp2/3 complex inhibitor, potentially affecting WIP's role in actin network formation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
An inhibitor of myosin light chain kinase, may indirectly affect actin dynamics and WIP activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing cAMP levels, it could influence signaling pathways that intersect with WIP's function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor, it may indirectly affect WIP activity by altering cell signaling related to the actin cytoskeleton. | ||||||