WFDC6A Inhibitors
WFDC6A inhibitors encompass a range of chemical compounds that interact with various signaling pathways and cellular processes that are potentially linked to the function of WFDC6A. Staurosporine, for example, is a broad kinase inhibitor that could impair the phosphorylation-dependent modulation of WFDC6A, while LY294002 and Wortmannin are specific PI3K inhibitors that may lead to a reduction in WFDC6A activity if it is associated with the PI3K/Akt pathway, critical for numerous cellular functions. Similarly, Rapamycin and MG132 act upon mTOR signaling and the ubiquitin-proteasome system, respectively, which could result in the downregulation of WFDC6A if it is involved in these pathways. In contrast, U0126, PD98059, and SB203580 target the MEK and p38 MAPK pathways, potentially impacting WFDC6A's role in these signaling cascades. ZM-447439 and SP600125, which inhibit Aurora kinases and JNK respectively, could also affect WFDC6A if it plays a part in cell cycle control or stress response mechanisms.
Furthermore, Brefeldin A disrupts the ARF1-mediated protein transport, which might impact the expression levels of WFDC6A if it relies on secretory pathways, and Cycloheximide, a classic protein synthesis inhibitor, could decrease WFDC6A levels by inhibiting its translation. Each inhibitor operates through distinct biochemical mechanisms, yet they collectively offer a comprehensive approach to potentially diminishing the functional activity of WFDC6A by targeting the protein's potential regulatory mechanisms and pathways. By understanding the specific interactions between these inhibitors and the biochemical pathways, insights into the functional inhibition of WFDC6A can be gained, providing a targeted approach to modulating its activity within the cellular context
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that blocks protein phosphorylation, which may inhibit WFDC6A if its function is modulated by phosphorylation events. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that diminishes the PI3K/Akt signaling pathway. If WFDC6A is regulated through this pathway, its activity could be reduced as this pathway influences various cellular functions including growth and survival. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor which could lead to the downregulation of WFDC6A if it is involved in the mTOR signaling pathway that regulates cell growth, proliferation, and survival. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of MEK1/2 which could inhibit WFDC6A by interfering with the MAPK/ERK pathway, potentially affecting proteins regulated by this signaling cascade. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A specific inhibitor of p38 MAPK, potentially reducing the activity of WFDC6A if it is involved in stress response pathways mediated by p38. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts protein transport by inhibiting the exchange of ADP-ribosylation factor 1 (ARF1), which could decrease WFDC6A expression if it relies on secretory pathways for its function. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, potentially decreasing the levels of WFDC6A if it has a high turnover rate. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that could lead to reduced activity of WFDC6A if it is regulated by ubiquitin-proteasome-mediated degradation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A specific inhibitor of MEK that blocks the MAPK/ERK pathway, which could inhibit WFDC6A indirectly if it is downstream or regulated by this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor that could reduce the activity of WFDC6A if its function is linked to the PI3K signaling pathway, which is involved in many cellular processes. | ||||||