WDR81 Inhibitors
WDR81 Inhibitors such as Bafilomycin A1 and Dynasore can disrupt vesicle trafficking, a cellular process that WDR81 is believed to be involved in. Bafilomycin A1 specifically inhibits the V-ATPase, which is vital for vesicular acidification, a key step in endosomal trafficking. Dynasore, on the other hand, impedes the function of dynamin, a GTPase crucial for the scission of clathrin-coated vesicles from the membrane.
Inhibitors that affect the actin cytoskeleton, such as Latrunculin A, ML141, and Y-27632, could indirectly influence the function of WDR81 by altering the cytoskeletal framework essential for vesicular movement. Similarly, Nocodazole and Phalloidin, which destabilize or stabilize microtubules and F-actin respectively, can disrupt the proper organization of the cytoskeleton, thereby affecting the intracellular trafficking routes that WDR81 might regulate. Chemicals like Endosidin2, Genistein, NSC23766, Pitstop 2, and Wortmannin target various aspects of intracellular signaling and vesicle formation or trafficking. Their inhibitory effects on tyrosine kinases, ESCRT components, Rac1, clathrin, and PI3K activities respectively can lead to a broad disruption of intracellular transport and signaling processes that are essential for the proper functioning of WDR81.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Inhibitor of the V-ATPase, which can disrupt vesicular acidification and trafficking. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibits dynamin, affecting vesicle scission and endocytosis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Inhibits tyrosine kinases, which can disrupt signaling pathways involved in vesicle trafficking. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Disrupts actin polymerization, which can affect cytoskeletal dynamics and vesicle movement. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
CDC42 inhibitor, affecting actin organization and vesicular transport. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Destabilizes microtubules, impacting intracellular transport and vesicular trafficking. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
Stabilizes F-actin, which can disrupt normal actin turnover and impact vesicle movement. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Inhibits clathrin, potentially affecting clathrin-mediated endocytosis and intracellular trafficking. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibitor of phosphoinositide 3-kinases, affecting various signaling pathways including vesicle formation and trafficking. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits ROCK, which can affect actin cytoskeleton dynamics and vesicle trafficking. | ||||||