WDR66 Inhibitors
WDR66 inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of the WDR66 protein, a member of the WD repeat-containing protein family. WDR66 is characterized by its WD40 repeat domains, which are highly conserved sequences that play a crucial role in facilitating protein-protein interactions and the formation of large multiprotein complexes. These complexes are essential for various cellular processes, including signal transduction, cytoskeletal organization, and molecular transport. WDR66, in particular, is thought to be involved in functions related to ciliary assembly and function, as well as intracellular transport mechanisms. By inhibiting WDR66, these compounds can interfere with its role in these cellular processes, leading to disruptions in the intricate networks that depend on its protein-interacting capabilities.
The mechanism of WDR66 inhibitors generally involves binding to the WD40 repeat domains or other functional regions of the WDR66 protein, preventing it from forming the necessary interactions with other cellular proteins. This inhibition disrupts WDR66's role in stabilizing protein complexes that are crucial for maintaining ciliary structure and function, as well as intracellular trafficking. As a result, processes such as molecular transport along cilia or the proper assembly of ciliary components may be affected. Researchers use WDR66 inhibitors to explore the specific biological roles of this protein, particularly in relation to its involvement in cellular architecture and signal coordination. These inhibitors serve as valuable tools for gaining a deeper understanding of how WDR66 contributes to the broader molecular machinery within cells, offering insights into the fundamental processes that rely on WD repeat-containing proteins to maintain structural and functional integrity across different cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. WDR66 is implicated in cell cycle regulation, and by selectively inhibiting CDK4/6, Palbociclib can disrupt the cell cycle progression, thereby inhibiting the function of proteins like WDR66 that are involved in this process. | ||||||
Ribociclib | 1211441-98-3 | sc-507367 | 10 mg | $450.00 | ||
Ribociclib serves a similar function as Palbociclib, selectively inhibiting CDK4/6. Given WDR66's role in cell cycle regulation, Ribociclib can hinder the cell cycle at specific phases where WDR66 is active, effectively inhibiting its function. | ||||||
Abemaciclib | 1231929-97-7 | sc-507342 | 10 mg | $110.00 | ||
Abemaciclib is another CDK4/6 inhibitor that works by halting cell cycle progression. This blockade can inhibit the function of cell cycle-associated proteins such as WDR66 by preventing the cell from advancing through stages of the cycle where WDR66 is functional. | ||||||
PHA-848125 | 802539-81-7 | sc-364581 sc-364581A | 5 mg 10 mg | $304.00 $555.00 | ||
Milciclib inhibits multiple cyclin-dependent kinases, including CDK2. Since WDR66 is associated with cell cycle progression, inhibiting CDK2 can impede the cycle's progression, thereby inhibiting WDR66's associated functions. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a potent inhibitor of CDKs, particularly CDK1, CDK2, and CDK5. By inhibiting these kinases, the chemical can disrupt the cell cycle and inhibit the function of proteins such as WDR66 that are involved in cell cycle control. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine selectively inhibits CDKs including CDK1, CDK2, and CDK7. WDR66, being associated with cell cycle regulation, can be functionally inhibited by the disruption of cell cycle progression caused by Roscovitine. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Dinaciclib is a potent inhibitor of CDKs, particularly CDK1, CDK2, CDK5, and CDK9. It can inhibit the function of cell cycle-related proteins like WDR66 by halting progression at phases where these proteins have regulatory roles. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
AZD5438 inhibits CDK1, CDK2, and CDK9. The inhibition of these kinases can lead to a blockade in cell cycle progression, which in turn can inhibit the function of proteins such as WDR66 that are involved in cell cycle regulation. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits several CDKs including CDK1, CDK2, CDK4, and CDK6. As WDR66 is involved in cell cycle processes, Flavopiridol can inhibit its function by disrupting the normal progression of the cell cycle. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is known to inhibit CDK2, CDK7, and CDK9. By inhibiting these kinases, SNS-032 can disrupt the regulatory roles of cell cycle-associated proteins like WDR66, thereby inhibiting its function. | ||||||