WDR19 Activators
WDR19 Activators encompass a range of compounds that indirectly enhance the functional activity of WDR19, primarily by modulating intracellular cyclic nucleotide levels and activating specific kinases. Forskolin, Epinephrine, Rolipram, IBMX, Cilostazol, Iloprost, Dopamine, Anagrelide, Terbutaline, Albuterol, Isoproterenol, and Sildenafil each contribute uniquely to this process. Forskolin increases cAMP levels, which activates PKA, subsequently phosphorylating substrates in WDR19 pathways, notably affecting ciliary functions and intracellular trafficking. Epinephrine, through β-adrenergic receptor stimulation, also elevates cAMP, enhancing WDR19 activity via similar PKA-mediated phosphorylation. Rolipram and IBMX, by inhibiting phosphodiesterases, lead to increased cAMP and cGMP levels, indirectly promoting WDR19 activity through PKA and PKG activation. This activation plays a crucial role in the regulation of WDR19 in ciliary dynamics and signaling.
In another layer of regulation, Cilostazol and Anagrelide, as PDE3 inhibitors, augment cAMP levels, subsequently activating PKA and influencing WDR19 pathways, particularly in ciliary maintenance. Iloprost, a prostacyclin analog, and Dopamine, through their respective receptor-mediated pathways, elevate cAMP, which indirectly boosts WDR19 activity. Terbutaline and Albuterol, β2-adrenergic agonists, enhance cAMP levels, leading to PKA activation and phosphorylation of substrates within WDR19-associated signaling pathways. This enhancement is pivotal in ciliary function and intracellular signaling. Lastly, Isoproterenol, a β-adrenergic agonist, and Sildenafil, a PDE5 inhibitor, elevate cAMP and cGMP levels, respectively. The resulting activation of PKA and PKG indirectly boosts WDR19's functional activity, underscoring its involvement in crucial cellular processes such as cilia function and intracellular transport. Through these multifaceted mechanisms, WDR19 Activators facilitate the enhancement of WDR19-mediated functions without the need for upregulating its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, leading to the activation of protein kinase A (PKA). PKA then phosphorylates substrates that are part of signaling pathways involving WDR19, thus indirectly enhancing WDR19 activity, particularly in ciliary functions and intracellular trafficking. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to β-adrenergic receptors, resulting in increased cAMP levels and PKA activation. This cascade indirectly enhances WDR19 activity by phosphorylating proteins in pathways where WDR19 is critical, especially in cilia-related cellular processes. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), leading to elevated cAMP levels and subsequent PKA activation. This indirectly influences WDR19 activity through the phosphorylation of substrates in WDR19-involved pathways, particularly impacting ciliary function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX, a non-selective inhibitor of phosphodiesterases, enhances both cAMP and cGMP levels. The activation of PKA and PKG indirectly promotes WDR19 activity by phosphorylating proteins within WDR19-associated signaling pathways, especially those related to ciliary dynamics. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol, a PDE3 inhibitor, increases cAMP levels, leading to PKA activation. PKA can then indirectly enhance WDR19 activity by modulating the signaling pathways involving WDR19, particularly in ciliary maintenance and cell signaling. | ||||||
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost, a prostacyclin analog, activates IP receptors, elevating cAMP and subsequently activating PKA. This leads to indirect enhancement of WDR19 activity, particularly influencing pathways related to cilia and intracellular transport. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, through D1-like receptor activation, increases neuronal cAMP levels. This elevation enhances WDR19 activity indirectly via PKA-mediated phosphorylation, impacting WDR19’s role in ciliary functions and signaling pathways. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $150.00 | ||
Anagrelide, a PDE3 inhibitor, raises cAMP levels, leading to PKA activation. The phosphorylation events mediated by PKA can indirectly enhance WDR19 activity, particularly in pathways related to cilia and intracellular trafficking. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Albuterol, another β2-adrenergic agonist, raises cAMP levels, activating PKA. The PKA-induced phosphorylation cascade indirectly augments WDR19 activity in ciliary function and intracellular signaling pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a β-adrenergic agonist, enhances adenylate cyclase activity, increasing cAMP levels. This surge in cAMP activates PKA, which then phosphorylates and activates substrates involved in WDR19-related pathways, thereby enhancing WDR19 functional activity. | ||||||