WDR19 Inhibitors
Chemical inhibitors of WDR19 function predominantly by disrupting microtubule dynamics or the regulatory pathways that control ciliary transport and assembly processes. Ciliobrevin A, for instance, impairs the hedgehog signaling pathway, which is critical for ciliogenesis, by inhibiting dynein. Since dynein motors are essential for the intraflagellar transport system where WDR19 operates, the inhibition of dynein by Ciliobrevin A can subsequently impair WDR19 function. Similarly, Mebendazole and Griseofulvin exert their inhibitory effects by interfering with microtubule polymerization, a process fundamental for the trafficking role of WDR19. Mebendazole destabilizes microtubules while Griseofulvin binds to tubulin, leading to microtubule disassembly. Both actions result in a compromised microtubule framework, thereby impeding WDR19's transport function within cilia.
Other chemical inhibitors, such as Colchicine, Vincristine, Nocodazole, Podophyllotoxin, and Thiabendazole, also target microtubule dynamics but through different mechanisms. Colchicine binds to tubulin, inhibiting its polymerization and the formation of microtubules, on which WDR19 relies for ciliary cargo transport. Vincristine and Podophyllotoxin are microtubule-destabilizing agents that inhibit the assembly of microtubules, while Nocodazole interferes directly with microtubule polymerization. Thiabendazole, like Mebendazole and Griseofulvin, disrupts microtubule polymerization, further supporting the inhibition of WDR19's role in ciliary function. Conversely, Paclitaxel stabilizes microtubules, preventing their depolymerization, which paradoxically disrupts the dynamic nature of microtubules required for WDR19's function. In addition, Monastrol and Alsterpaullone disrupt processes upstream of microtubule-based transport. Monastrol inhibits the kinesin Eg5, affecting spindle formation and potentially the anterograde transport within cilia where WDR19 is active. Alsterpaullone targets cyclin-dependent kinases, which are integral to the regulation of ciliogenesis and intraflagellar transport, thereby disrupting WDR19's associated activities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
HPI-4 | 302803-72-1 | sc-358720 sc-358720A | 5 mg 25 mg | $133.00 $530.00 | ||
Ciliobrevin A (HPI-4) is a hedgehog signaling pathway inhibitor that can indirectly disrupt the function of WDR19 by inhibiting dynein. WDR19 is a component of the intraflagellar transport system necessary for ciliogenesis. Inhibition of dynein therefore can lead to impaired ciliogenesis, where WDR19 plays a role, leading to a functional inhibition of WDR19's role in this process. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $45.00 $87.00 | 2 | |
Mebendazole, an antiparasitic compound, has been shown to disrupt microtubule polymerization. WDR19 is implicated in microtubule dynamics as part of the intraflagellar transport system. By destabilizing microtubules, Mebendazole can impair the trafficking function of WDR19, thereby functionally inhibiting its activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin and prevents its polymerization, disrupting microtubule formation. As WDR19 is involved in cargo transport along microtubules in cilia, Colchicine's action would inhibit the proper functioning of WDR19 by preventing the formation of the microtubules required for its transport role. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules and prevents their depolymerization, which can paradoxically disrupt microtubule dynamics. Since WDR19 is involved in the intraflagellar transport that relies on dynamic microtubules, the stabilization effect of Taxol can lead to functional inhibition of WDR19 by preventing proper microtubule functioning. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule-polymerization inhibitor that can interfere with microtubule assembly. As WDR19 relies on microtubule tracks for ciliary cargo transport, its function can be inhibited by Nocodazole through the impairment of microtubule structure and dynamics. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, causing disassembly. Since WDR19's function is dependent on microtubule-based transport within cilia, Griseofulvin can inhibit WDR19 by preventing the proper assembly and function of microtubules, thereby disrupting WDR19's role in intraflagellar transport. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin is a microtubule-destabilizing agent which can lead to the inhibition of microtubule assembly. As WDR19 is involved in intraflagellar transport processes that are dependent on microtubules, the disruption of microtubule dynamics by Podophyllotoxin can functionally inhibit WDR19 by preventing the formation of structures necessary for its activity. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor that disrupts mitotic spindle formation. By impeding kinesin function, Monastrol could potentially inhibit the trafficking role of WDR19 in intraflagellar transport, as kinesin motors are involved in anterograde transport within cilia, where WDR19 operates. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $103.00 $210.00 $6132.00 | 2 | |
Emodin has been identified as a kinase inhibitor with multiple targets. It can inhibit the function of WDR19 by interfering with kinases that are involved in the regulation of ciliogenesis and intraflagellar transport, processes where WDR19 is a critical component. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $31.00 $82.00 $179.00 $306.00 $561.00 | 5 | |
Thiabendazole interferes with microtubule polymerization. Because WDR19 is part of the intraflagellar transport system relying on microtubules, Thiabendazole can inhibit WDR19 function by disrupting the microtubule structures that are essential for its role in ciliary function. | ||||||