WDR18 Inhibitors
WDR18 inhibitors are a class of chemicals that primarily aim to target the functions and pathways WDR18 is known to be involved in. This is especially relevant for ribosomal biogenesis and DNA damage repair pathways, among other cellular processes. Chemicals such as Rapamycin and Actinomycin D inhibit the ribosome biogenesis pathway by affecting mTOR signaling and RNA polymerase activity, respectively. This means that they have to directly attenuate the functional roles of WDR18 in ribosome production. On the other hand, Cisplatin and Camptothecin disrupt DNA structures and act as direct obstacles to DNA damage repair mechanisms.
Another aspect to consider is the involvement of WDR18 in complex cellular pathways, such as DNA repair, ribosome biogenesis, and chromosomal segregation. Chemicals like ZM 447439 and Bortezomib target the Aurora kinase and the proteasome complex respectively. Aurora kinase is vital for chromosomal segregation, and its inhibition can lead to disruption of pathways involving WDR18. Proteasome inhibition by Bortezomib can affect the stability and turnover of proteins, thereby affecting pathways that WDR18 is part of.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
WDR18 is implicated in ribosome biogenesis. Rapamycin inhibits mTOR, thereby reducing ribosomal RNA synthesis, and can reduce WDR18's functionality. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
It intercalates into DNA, disrupting the transcription process. Given that WDR18 is involved in ribosomal biogenesis, inhibiting transcription could indirectly limit its role. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
WDR18 is implicated in DNA damage repair. Cisplatin forms intrastrand crosslinks in DNA, which would necessitate repair pathways that may involve WDR18. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Topoisomerase I inhibitor affecting DNA unwinding, which may disturb processes where WDR18 is active in DNA repair. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
PARP inhibitor; as WDR18 has been suggested to be involved in DNA repair, inhibiting PARP can impair its associated functions. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Protein synthesis inhibitor affecting ribosomal function, indirectly inhibiting WDR18's role in ribosome biogenesis. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase, affecting DNA synthesis and potentially the roles of WDR18 in DNA repair and ribosome biogenesis. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Aurora kinase inhibitor, potentially disrupting pathways where WDR18 may act in chromosomal segregation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor; could impact protein turnover, including degradation of WDR18 or proteins it interacts with. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor affecting multiple cellular pathways, potentially including those involving WDR18. | ||||||