WDR11 Inhibitors
WDR11 inhibitors are compounds that can influence the various biological processes and pathways involving WDR11. These compounds primarily target the Hedgehog signaling pathway, protein trafficking, and ciliogenesis, all of which are relevant to WDR11's function. Inhibitors of the Hedgehog signaling pathway like Cyclopamine, Vismodegib, and GANT61 can be particularly relevant. By modulating this pathway, these compounds may affect WDR11's role in regulating the proteolytic processing of GLI3 and its cooperation with EMX1 in gene expression and gonadotropin-releasing hormone production. Compounds like Bortezomib and Rapamycin, known for their roles in influencing protein degradation and synthesis, might also have an effect on the stability and function of proteins that interact with WDR11 or are involved in pathways where WDR11 plays a role.
Furthermore, compounds that affect Golgi function and vesicle trafficking, like Tunicamycin, Golgicide A, and Brefeldin A, could be crucial in studying WDR11's role in vesicle tethering and its cooperation with TBC1D23 and golgins. These modulators provide valuable tools for investigating WDR11's role in the Hedgehog signaling pathway, ciliogenesis, protein processing, and vesicle tethering, enhancing our understanding of its biological functions.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
A specific inhibitor of the Hedgehog (Hh) signaling pathway, could indirectly affect WDR11's role in this pathway. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Another Hedgehog pathway inhibitor, used to target aberrant Hh signaling, potentially impacting WDR11-associated functions. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
Inhibits GLI-mediated transcription, part of the Hedgehog pathway, and may indirectly influence WDR11's regulatory role on GLI3. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
A naturally occurring inhibitor of the Hedgehog signaling pathway, potentially affecting WDR11-related processes. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $135.00 | 5 | |
An antagonist of Smoothened (SMO), a key protein in the Hedgehog pathway, could indirectly modulate WDR11's function. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Activates the Hedgehog pathway; could be used to study the role of WDR11 in this pathway through pathway activation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor, might indirectly affect the stability of proteins involved in the pathways where WDR11 is active. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, known to affect protein synthesis and degradation, could indirectly impact WDR11's function in ciliogenesis. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
A more potent mTOR inhibitor than Rapamycin, potentially affecting processes related to WDR11. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
An inhibitor of N-linked glycosylation, can affect protein trafficking and might indirectly influence WDR11's role in vesicle tethering. | ||||||