VWA8 Activators
VWA8 activators encompass a range of chemical entities that modulate pathways or cellular processes relevant to the functionality of the VWA8 protein. These activators work through various mechanisms, such as influencing secondary messenger systems, altering enzyme activities, or modulating signal transduction pathways, to ultimately affect the activity of VWA8, either directly or via its interaction partners. The action of these activators is centered around the modulation of signaling cascades that include but are not limited to cAMP/PKA pathways, PI3K-AKT-mTOR axes, and MAPK-related networks. The engagement of these chemicals with their respective targets leads to a cascade of intracellular events that can pivotally configure the operational landscape of VWA8.
The spectrum of VWA8 activators presents a complex biochemical interplay within the cellular milieu. By impacting signaling pathways that are fundamental to cellular communication and response, these activators can indirectly sway the activity of VWA8. For instance, compounds that enhance PKA activity through elevating cAMP levels can lead to phosphorylation events that affect the proteins interacting with VWA8, thereby modulating its activity. Similarly, chemicals that inhibit kinases like PI3K, MEK, or mTOR, can cause downstream effects on cellular signaling networks, resulting in an altered environment that may incidentally prime VWA8 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases levels of cAMP, a secondary messenger that can enhance protein kinase A (PKA) activity. PKA can phosphorylate substrates that may interact with VWA8, leading to its functional modulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, enzymes that break down cAMP and cGMP. By preventing cAMP degradation, IBMX can indirectly maintain PKA activation, potentially affecting proteins that associate with VWA8. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
As an activator of G proteins, sodium fluoride can indirectly lead to increased cAMP levels, enhancing PKA activity, which could affect proteins associated with VWA8. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4, which metabolizes cAMP in the brain. Inhibition of PDE4 prevents cAMP breakdown, potentially enhancing PKA-mediated processes involving VWA8. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, leading to altered AKT signaling. Through this mechanism, downstream effectors that may regulate VWA8 are affected, as PI3K-AKT signaling is pivotal for various cellular processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an inhibitor of mTOR, rapamycin can modulate the mTOR signaling pathway, which is involved in cellular growth and metabolism. The changes in mTOR activity can influence the overall protein synthesis environment, indirectly affecting VWA8. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, a protein kinase that responds to stress stimuli. By modulating the activity of p38 MAPK, it can influence downstream signaling pathways that could intersect with VWA8-related processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, affecting the ERK pathway. Alteration of MEK/ERK signaling can lead to changes in various phosphorylation states of proteins, potentially affecting those that interact with VWA8. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, modulating the activity of AP-1 transcription factor. Changes in AP-1 activity can alter the transcription of genes whose products may be involved in the same cellular pathways as VWA8. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can alter phosphorylation patterns in cells, potentially affecting signaling pathways that intersect with those involving VWA8. | ||||||