Vmn2r87 Activators
Chemical activators of Vmn2r87 employ a variety of intracellular signaling mechanisms to achieve their effects. Forskolin and Isoproterenol, for instance, both work to directly increase the levels of cyclic AMP (cAMP) within the cell. Forskolin achieves this by directly stimulating adenylyl cyclase, which catalyzes the conversion of ATP to cAMP, whereas Isoproterenol activates beta-adrenergic receptors, which then engage Gs proteins to stimulate adenylyl cyclase. The rise in cAMP levels activates protein kinase A (PKA), which can then phosphorylate and activate Vmn2r87. Similarly, Dopamine and Adrenaline also raise cAMP levels, with dopamine acting through D1-like receptors and adrenaline through beta-adrenergic receptors, leading to PKA-mediated phosphorylation of Vmn2r87.
Other compounds, such as Histamine, Serotonin, Glutamate, Angiotensin II, Endothelin-1, Oxytocin, Pilocarpine, and Anandamide, operate through phospholipase C (PLC) pathways. Upon binding to their respective G protein-coupled receptors (GPCRs), these substances activate PLC, which then hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 facilitates the release of calcium ions from intracellular stores, while DAG activates protein kinase C (PKC). The activation of PKC is a crucial step, as it can then go on to phosphorylate Vmn2r87, culminating in the activation of the protein. Each of these chemicals engages with specific receptors that are linked to the PLC pathway, thus initiating the cascade of events leading to the activation of Vmn2r87.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol binds to and activates beta-adrenergic receptors, which subsequently engage Gs proteins to stimulate adenylyl cyclase, thereby increasing intracellular cAMP levels. The activation of PKA by cAMP can result in the phosphorylation and activation of Vmn2r87. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its interaction with G protein-coupled histamine receptors, can stimulate phospholipase C (PLC) activity. PLC generates inositol trisphosphate (IP3) and diacylglycerol (DAG) which can activate protein kinase C (PKC). PKC-mediated phosphorylation can activate Vmn2r87. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin binds to 5-HT receptors that can activate PLC, leading to the production of IP3 and DAG. The activation of PKC by DAG can lead to the phosphorylation and subsequent activation of Vmn2r87 within serotonin signaling pathways. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
Glutamate can activate metabotropic glutamate receptors that are coupled to G proteins that stimulate PLC. The production of IP3 and DAG from this activity can lead to PKC activation, which in turn can phosphorylate and activate Vmn2r87. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II engages with its G protein-coupled receptors to activate PLC. The resulting increase in IP3 and DAG levels can activate PKC, which subsequently can phosphorylate and activate Vmn2r87 in angiotensin II signaling pathways. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $60.00 $180.00 $337.00 $663.00 $969.00 $1836.00 | 4 | |
Oxytocin interacts with its receptor, a GPCR, which can stimulate PLC activity. The subsequent production of IP3 and DAG can lead to PKC activation. PKC then can phosphorylate and activate Vmn2r87 in oxytocin-regulated signaling pathways. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, through D1-like receptors, can increase intracellular cAMP levels, leading to the activation of PKA. PKA then can phosphorylate and activate Vmn2r87 as part of dopamine signaling pathways. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Adrenaline interacts with beta-adrenergic receptors, activating Gs proteins that stimulate adenylyl cyclase and increase cAMP levels. The cAMP activates PKA, which can then phosphorylate and activate Vmn2r87. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $255.00 | 1 | |
Pilocarpine, through muscarinic acetylcholine receptors, can activate Gq proteins that stimulate PLC, leading to the production of IP3 and DAG. The activation of PKC by DAG can phosphorylate and activate Vmn2r87. | ||||||