Vmn1r123 Activators
Vomeronasal 1 receptor 123 Activators are a diverse class of compounds that engage various signaling pathways to enhance the function of vomeronasal 1 receptor 123 (V1R123). Compounds such as sodium fluoride and carbachol directly activate G-proteins, which are critical components of the signaling pathways utilized by V1R123. By stimulating G-protein activity, these chemicals enhance the receptor's ability to transmit sensory information. Similarly, forskolin and isoproterenol increase intracellular cAMP levels, potentiating the signaling cascades in which V1R123 participates. This elevation in cAMP can lead to an enhanced sensory signaling function of V1R123.
Other compounds like ionomycin and capsaicin increase intracellular calcium levels. Since V1R123 is involved in calcium-mediated signal transduction, the elevated calcium levels due to the activation of ionomycin and capsaicin can enhance the function of V1R123. Pilocarpine and acetylcholine, which are agonists for muscarinic acetylcholine receptors, and nicotine, which activates nicotinic acetylcholine receptors, can influence GPCR signaling. This modulation can have downstream effects that enhance V1R123 activity. Additionally, ATP and histamine bind to their respective purinergic andhistaminergic receptors, both of which are GPCRs. This binding can lead to alterations in the G-protein signaling pathways that are capable of enhancing the signaling function of V1R123. Lastly, serotonin serves as an agonist for serotonin receptors, and its action on these receptors can also lead to signal transduction effects that ultimately enhance the functional activity of V1R123.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium fluoride acts as a G-protein activator. The activation of G-proteins can lead to the stimulation of vomeronasal 1 receptor 123 (V1R123) by promoting signal transduction pathways that V1R123 is part of, enhancing its sensory signaling functions. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate the phospholipase C pathway, which in turn can enhance the function of V1R123 due to its involvement in calcium-mediated signal transduction. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels via G-protein-coupled receptor (GPCR) signaling. The increase in cAMP levels can indirectly enhance V1R123 function as it is a GPCR and its signaling can be potentiated by elevated cAMP. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $255.00 | 1 | |
Pilocarpine is a muscarinic acetylcholine receptor agonist. It can indirectly enhance the function of V1R123 by activating related GPCRs and modulating intracellular pathways that can influence V1R123 signaling. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
Carbachol is a cholinergic agonist that can activate G-proteins. By activating G-proteins, carbachol can enhance the signal transduction pathways associated with V1R123, possibly leading to increased receptor function. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates the TRPV1 receptor, which can lead to an increase in intracellular calcium levels. This increase can indirectly enhance V1R123 activity by affecting the calcium-sensitive signaling pathways it is associated with. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
ATP can serve as a ligand for purinergic receptors, which are also GPCRs. By activating these receptors, ATP may indirectly enhance V1R123 function via G-protein-mediated signaling pathways. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to its GPCRs, leading to an alteration in intracellular signaling pathways. These alterations can enhance V1R123 function by influencing the signaling networks in which the receptor operates. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Serotonin acts on its receptors, which are part of the GPCR family. The activation of these receptors can lead to signal transduction effects that enhance the signaling capacity of V1R123. | ||||||