Vav Activators
Common Vav Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Dexamethasone CAS 50-02-2, PMA CAS 16561-29-8, Cyclosporin A CAS 59865-13-3 and Resveratrol CAS 501-36-0.
Vav Activators represent a class of molecules that play a critical role in intracellular signaling pathways, particularly in the context of immune cell activation and cytoskeletal regulation. The term "Vav" refers to a family of guanine nucleotide exchange factors (GEFs) that are expressed in various cell types, including immune cells like T cells, B cells, and macrophages. These proteins act as molecular switches, facilitating the exchange of GDP for GTP on Rho-family GTPases, which in turn regulates downstream signaling events.
Vav proteins are characterized by multiple domains, including a calponin homology (CH) domain, a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, and a cysteine-rich domain (CRD). These domains work in concert to regulate the activity of Rho GTPases, which are pivotal in orchestrating processes such as actin cytoskeleton remodeling, cell migration, and immune cell activation. When a cell is stimulated, Vav Activators are recruited to the plasma membrane, where they undergo a series of conformational changes and interactions with other proteins. This leads to the activation of Rho GTPases, initiating downstream signaling cascades that impact various cellular functions. Understanding the mechanisms of Vav activation is crucial in unraveling the complexities of immune cell signaling.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of Vitamin A, retinoic acid can modulate the expression of various genes, potentially including Vav, through its action on retinoic acid receptors. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid that can modulate the expression of various genes. In some contexts, dexamethasone might influence Vav expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diacylglycerol (DAG) analog that activates protein kinase C (PKC). PMA can modulate the expression of various genes, potentially including Vav. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Immunosuppressant suggested compound that may influence Vav expression as part of its broader effects on T cell activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenolic compound that might influence Vav expression, potentially through its anti-inflammatory and antioxidant effects. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase, leading to increased cAMP levels. Forskolin might influence Vav expression as part of broader changes in cellular signaling. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
A component of bacterial cell walls, LPS can stimulate immune cells, potentially leading to changes in Vav expression as part of the broader immune response. | ||||||