Vasculin Inhibitors
Vasculin inhibitors encompass a wide array of chemicals that indirectly decrease the functional activity of Vasculin. Predominantly, these compounds act by modifying the vasoconstrictive and vasodilatory balance within the vascular system. For instance, Sodium nitroprusside, a nitric oxide donor, and a group of drugs known as calcium channel blockers, including Verapamil, Nifedipine, Amlodipine, and Diltiazem, work by promoting vasodilation. These compounds inhibit the influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle, leading to muscle relaxation and vasodilation. This indirectly inhibits Vasculin by reducing the demand for its vasoconstrictive action.
Another class of Vasculin inhibitors includes endothelin receptor antagonists and angiotensin II receptor antagonists. Bosentan, an endothelin receptor antagonist, inhibits the vasoconstrictive action of endothelin-1, indirectly reducing Vasculin activity. Angiotensin II receptor antagonists such as Losartan, Candesartan, and Telmisartan block the vasoconstrictive effects of angiotensin II, indirectly decreasing the functional activity of Vasculin. In this way, all these chemicals can indirectly inhibit Vasculin by promoting vasodilation or inhibiting vasoconstriction, thereby reducing the need for Vasculin's vasoconstrictive properties.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Sodium nitroprusside induces the release of nitric oxide (NO). NO promotes vasodilation, which can indirectly decrease Vasculin activity by reducing the need for its vasoconstrictive properties. | ||||||
Bosentan | 147536-97-8 | sc-210957 | 10 mg | $195.00 | 3 | |
Bosentan is an endothelin receptor antagonist that inhibits endothelin-1, which is a potent vasoconstrictor. By blocking this action, bosentan indirectly decreases the activity of Vasculin which is also involved in vasoconstriction. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Hydralazine is a direct-acting vascular smooth muscle relaxant. By promoting muscle relaxation, hydralazine induces vasodilation, which can decrease the functional activity of Vasculin by reducing the necessity for vasoconstriction. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that inhibits the influx of extracellular calcium into myocardial and vascular smooth muscle cells, causing vasodilation. This process indirectly inhibits Vasculin by reducing the need for its vasoconstrictive action. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and indirectly reduces Vasculin activity. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Amlodipine is a long-acting calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Its vasodilatory effect indirectly reduces Vasculin activity. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem, a calcium channel blocker, inhibits the influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. It induces vasodilation and indirectly reduces Vasculin activity. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan is an angiotensin II receptor blocker (ARB). By blocking the vasoconstrictive effect of angiotensin II, losartan indirectly decreases the functional activity of Vasculin. | ||||||
Candesartan | 139481-59-7 | sc-217825 sc-217825B sc-217825A | 10 mg 100 mg 1 g | $47.00 $94.00 $151.00 | 6 | |
Candesartan is an angiotensin II receptor antagonist that selectively blocks the angiotensin II type 1 receptor (AT1). By blocking the AT1 receptor, Candesartan prevents these actions of angiotensin II, leading to lowered blood pressure and reduced vasoconstriction. This indirect effect can reduce the need for Vasculin's vasoconstrictive action, thereby reducing its functional activity. | ||||||
Telmisartan | 144701-48-4 | sc-204907 sc-204907A | 50 mg 100 mg | $72.00 $94.00 | 8 | |
Telmisartan is an angiotensin II receptor antagonist with selective type 1 receptor (AT1) blocking properties. By blocking the vasoconstrictive effect of angiotensin II, Telmisartan indirectly decreases the functional activity of Vasculin. | ||||||