VASA Inhibitors
VASA inhibitors are a chemical class of compounds that are characterized by their ability to selectively inhibit the activity of the VASA protein. VASA, also known as DEAD-box helicase, is an important RNA helicase that plays a crucial role in various biological processes, particularly in RNA metabolism. VASA inhibitors are designed to specifically target the ATPase activity of VASA, preventing its proper function and disrupting the normal processes associated with this protein. By interfering with the ATPase activity, VASA inhibitors can modulate the RNA-related pathways regulated by VASA, such as RNA translation, RNA splicing, and RNA transport.
The mechanism of action of VASA inhibitors involves binding to specific sites on the protein, which leads to conformational changes and subsequent inhibition of its ATPase activity. This inhibition of VASA's ATPase activity may have implications in cellular processes that rely on VASA, leading to downstream effects on gene expression, cellular differentiation, and development. The development and exploration of VASA inhibitors provide valuable insights into the fundamental understanding of VASA's role in RNA metabolism and may open up new avenues for research and applications in various fields of biology and biotechnology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Amodiaquine been found to inhibit Vasa helicase activity. It interferes with the ATP-binding site of Vasa helicase, leading to inhibition of its ATPase activity and subsequent disruption of RNA unwinding. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is a natural product found in Streptomyces bacteria and is known for its anticancer properties. It has been shown to inhibit Vasa helicase activity by binding to its ATP-binding site and blocking ATP hydrolysis. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin is primarily used for certain parasitic infections and has been found to inhibit Vasa helicase activity. It binds to Vasa helicase and interferes with its ATP-binding ability, resulting in inhibition of RNA unwinding. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamides are a group of natural compounds found in plants. They have been reported to inhibit Vasa helicase activity by binding to its ATP-binding site and interfering with ATP hydrolysis. | ||||||