VASA Activators
VASA is a critical ATP-dependent RNA helicase that plays a pivotal role in germ cell development, particularly in spermatogenesis and oogenesis. It is primarily involved in the regulation of mRNA translation, ensuring the correct expression of genes essential for germ cell maturation and genomic integrity. The activation and proper function of VASA are crucial for the development of healthy germ cells, as it facilitates the remodeling of chromatin structure, supports the repair of DNA damage, and ensures the accurate segregation of chromosomes during meiosis. The protein's activity is tightly regulated through various signaling pathways, including the PI3K/Akt and mTOR pathways, which influence its phosphorylation state and, consequently, its activity.
The general mechanism of VASA activation involves its integration into these cellular signaling pathways, which are essential for the cellular response to environmental cues and stresses. By participating in these pathways, VASA directly contributes to the regulation of germ cell fate, promoting their development and protecting them from apoptosis. The chemicals listed above have been selected based on their ability to indirectly influence the signaling pathways that regulate VASA activity. These chemicals do not activate VASA directly; instead, they modulate cellular pathways that, in turn, ensure the optimal activity of VASA in germ cell development. For instance, compounds that activate the PI3K/Akt pathway support the phosphorylation and activation of VASA, which is essential for its role in germ cell development. Similarly, substances that influence the stress response pathways or the mTOR signaling pathway can indirectly contribute to the activation of VASA by creating a favorable environment for its function in germ cell maturation and development. Through these indirect mechanisms, the selected chemicals play a crucial role in supporting the activation and function of VASA, thereby contributing to the successful development of germ cells and the maintenance of genomic integrity within these cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A, by disrupting endocrine function, indirectly promotes the phosphorylation of proteins involved in the PI3K/Akt pathway, which is known to enhance the activation and function of VASA by facilitating its role in mRNA translation and germ cell development. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which in turn modulates the PI3K/Akt signaling pathway. This pathway's activation is critical for the phosphorylation state and activity of VASA, particularly in promoting germ cell development and maintaining genomic integrity in germ cells. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
17β-Estradiol binds to estrogen receptors, initiating a cascade that leads to the activation of the PI3K/Akt pathway. This pathway supports the activation of VASA, essential for its role in the regulation of germ cell maturation and spermatogenesis. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $138.00 $400.00 | ||
Triclosan influences the fatty acid synthesis pathway, indirectly affecting the MAPK pathway, which is linked to cellular stress responses. This modulation enhances the activation of VASA by ensuring its stabilization and proper function in germ cell development under stress conditions. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, through its action on mTOR, indirectly affects the phosphorylation levels of proteins in the mTOR signaling pathway. This modulation can lead to an enhanced activation of VASA by promoting its role in germ cell development and differentiation. | ||||||
Lithium Chloride | 7447-41-8 | sc-203110 sc-203110A sc-203110B sc-203110C sc-203110D sc-203110E | 50 g 250 g 1 kg 2.5 kg 5 kg 10 kg | $32.00 $62.00 $173.00 $347.00 $614.00 $1163.00 | 8 | |
Lithium chloride activates the Wnt/β-catenin pathway, which has been implicated in the regulation of germ cell fate and development. This activation can support the function of VASA in germ cell maturation and the regulation of meiotic progression. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, which in turn influences the mTOR pathway, a regulator of cellular growth and metabolism. This activation indirectly supports VASA function by promoting germ cell development and maintaining genomic stability in these cells. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, alters chromatin structure and affects gene expression. This modification can lead to the activation of signaling pathways that support VASA function in germ cell development and maturation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates the NF-κB pathway, which is involved in cellular stress responses and survival. This modulation can indirectly enhance the activation of VASA by promoting cellular environments that support germ cell development and genomic stability. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, through glucocorticoid receptor activation, modulates the expression of genes involved in the stress response. This modulation can indirectly promote the activation of VASA by facilitating its role in germ cell development under stress conditions. | ||||||