VAMP-2 Inhibitors
VAMP-2 inhibitors belong to a specific class of chemical compounds designed to target and modulate the activity of the vesicle-associated membrane protein 2 (VAMP-2), also known as synaptobrevin-2. VAMP-2 is a crucial protein involved in the process of vesicle fusion, a fundamental mechanism in intracellular transport and neurotransmitter release within neurons. These inhibitors are primarily developed for their ability to interfere with VAMP-2-mediated membrane fusion events, disrupting the normal functioning of synaptic vesicles.
The chemical structure of VAMP-2 inhibitors often comprises small molecules or peptides specifically designed to interact with key regions of the VAMP-2 protein. These compounds typically feature hydrophobic moieties and may possess various functional groups that facilitate their binding to VAMP-2. By interfering with VAMP-2, these inhibitors disrupt the formation of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, which is essential for the fusion of synaptic vesicles with the plasma membrane. Consequently, this disruption leads to a decrease in neurotransmitter release, affecting synaptic transmission and communication between neurons. The development and study of VAMP-2 inhibitors are crucial in understanding the intricate processes governing neuronal signaling and vesicular trafficking, providing valuable insights into the molecular mechanisms underlying various neurological disorders. Researchers are continually exploring the applications of VAMP-2 inhibitors in the context of basic neuroscience research and drug discovery, seeking to unravel the intricacies of synaptic function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid might inhibit VAMP-2 expression by modulating gene expression and chromatin structure through its histone deacetylase inhibitory activity, potentially affecting the transcriptional regulation of VAMP-2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin potentially reduces VAMP-2 expression by inhibiting the mammalian target of rapamycin (mTOR) pathway, which plays a role in protein synthesis and cell growth. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine might inhibit VAMP-2 expression by causing DNA demethylation, which could lead to altered gene expression patterns, including the downregulation of VAMP-2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, has the potential to modulate VAMP-2 expression by altering chromatin structure and enhancing gene transcription accessibility. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may modulate VAMP-2 expression through its role in cell differentiation and growth, potentially affecting neural development and synaptic plasticity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, as a histone deacetylase inhibitor, might influence VAMP-2 expression by changing chromatin structure and enhancing the transcription of certain genes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine has the potential to affect VAMP-2 expression indirectly through its impact on lysosomal function and autophagy, which are involved in protein degradation and turnover. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine might inhibit VAMP-2 expression through its DNA demethylating activity, potentially leading to altered transcriptional regulation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol might modulate VAMP-2 expression through its action on estrogen receptors, which are involved in the regulation of gene transcription and neural functions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has the potential to alter VAMP-2 expression through its effects on various signaling pathways and its role in cellular antioxidant defense, which could affect neuronal function and plasticity. | ||||||