UTP11L Inhibitors
UTP11L Inhibitors are a collection of chemical compounds that impede the functional activity of UTP11L, a protein involved in ribosome biogenesis and pre-rRNA processing. Rapamycin, by suppressing mTOR activity, indirectly impacts UTP11L's role in ribosome assembly given the sensitivity of ribosome biogenesis to cellular growth signals. Likewise, LY 294002 disrupts the PI3K/AKT/mTOR signaling axis, leading to a decrease in ribosome production and thus indirectly affecting UTP11L activity. Leptomycin B may cause the retention of UTP11L within the nucleus by blocking CRM1-mediated export, potentially reducing its functionality if nuclear-cytoplasmic transport is critical for its action. Staurosporine and Roscovitine serve to further this inhibitory effect by targeting kinase pathways and cyclin-dependent kinases, respectively, which could be crucial for the optimal functioning or proper localization of UTP11L.
In addition to these pathway-specific inhibitors, compounds like Actinomycin D and 5-Fluorouracil exert their effects by intercalating into DNA and disrupting nucleotide synthesis, respectively, which can lead to a broad decline in transcriptional activity, indirectly diminishing the levels and function of UTP11L. Triptolide and CX-5461 specifically target RNA polymerase activity, thereby reducing rRNA synthesis and potentially lowering UTP11L's involvement in rRNA processing. BMH-21, through its binding to RNA polymerase I, could lead to a similar outcome by decreasing the substrate availability for UTP11L-mediated processing. The proteasome inhibitor Bortezomib may indirectly influence UTP11L function by inducing proteotoxic stress and shifting cellular priorities away from processes like ribosome biogenesis. Lastly, Omega-3 fatty acids, through their ability to modulate signal transduction and gene expression, may indirectly attenuate UTP11L function by influencing the regulatory mechanisms of ribosome assembly and cell growth.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is a central molecule in regulating cell growth and proliferation, indirectly diminishing UTP11L functionality due to its role in ribosome biogenesis, which is sensitive to the cellular growth and proliferation status. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B inhibits the export of proteins from the nucleus by directly binding to exportin 1 (CRM1), potentially leading to the nuclear accumulation and subsequent functional inhibition of UTP11L if it relies on nuclear-cytoplasmic shuttling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that disrupts the PI3K/AKT/mTOR signaling pathway, leading to reduced ribosome biogenesis activity and indirectly to the diminishment of UTP11L function which is involved in pre-rRNA processing and ribosome assembly. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a potent kinase inhibitor, could indirectly inhibit UTP11L by interfering with kinase-dependent signaling pathways that may be essential for its function or localization within the cell. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a selective inhibitor of cyclin-dependent kinases (CDKs) which may indirectly decrease UTP11L function by altering the cell cycle and consequently the demand for ribosome biogenesis in which UTP11L is involved. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA, inhibiting transcription. This can indirectly diminish UTP11L function by preventing its transcription and thus decreasing its protein levels and its involvement in ribosome biogenesis. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a diterpene triepoxide that inhibits RNA polymerase I, II, and III, leading to reduced transcription and potentially diminishing the function of UTP11L by lowering its RNA and protein levels. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
CX-5461 selectively inhibits RNA polymerase I transcription, leading to a decrease in rRNA synthesis and possibly the functional inhibition of UTP11L due to its role in pre-ribosomal RNA processing. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
BMH-21 binds to RNA polymerase I and induces its degradation, which could lead to diminished UTP11L function as it is involved in the processing of pre-rRNA, a substrate of polymerase I. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is an antimetabolite that interferes with nucleotide synthesis, potentially leading to the functional inhibition of UTP11L by depleting the nucleotide pools necessary for rRNA synthesis and processing. | ||||||