USP17L29 Activators
Common USP17L29 Activators include, but are not limited to MG-132 [Z-Leu- Leu-Leu-CHO] CAS 133407-82-6, Epoxomicin CAS 134381-21-8, PR 619 CAS 2645-32-1, N-Ethylmaleimide CAS 128-53-0 and PYR 41 CAS 418805-02-4.
USP17L29, formally recognized as Ubiquitin Specific Peptidase 17 Like Family Member 29, is intricately intertwined with the deubiquitinating enzyme (DUB) family. As a protein-coding gene, it's deeply entrenched in pathways related to deubiquitination and the metabolism of proteins. Characterized by its cysteine-type peptidase activity and cysteine-type deubiquitinase activity, USP17L29 plays a nuanced role in cellular processes. One of its salient functions is in cell apoptosis, where it actively cleaves ubiquitin fusion protein substrates. This enzyme's activity is pivotal in regulating protein stability, activity, and cellular location, with profound implications for cellular functions like cell cycle progression, DNA damage repair, and diverse signaling pathways.
Activators targeting USP17L29 are conceptualized as chemical compounds aiming to enhance the enzyme's inherent activity. The mechanism of action could involve direct enhancement of the enzyme's affinity for its substrates or facilitating structural alterations to render the catalytic site more accessible. It's noteworthy that while the related gene USP17 has documented roles in cell migration, leukocyte growth, differentiation, and is known to be induced by specific cytokines like CXCL12, CXCL8, IL-4, and IL-6, the exact function and pathway involvement of USP17L29 still remain shrouded in mystery. The exploration and development of USP17L29 activators present a tantalizing avenue for understanding the broader impact of modulating this enzyme within the complex ubiquitin-proteasome system. Further research is vital to unveil the myriad interactions and potential roles of USP17L29 in cellular and physiological processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that could potentially increase USP17L29 expression by inhibiting protein degradation, including deubiquitination processes. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a proteasome inhibitor that could affect USP17L29 expression by modulating protein degradation pathways. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-spectrum deubiquitinase inhibitor that might increase USP17L29 expression by inhibiting deubiquitination processes. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
NEM is a deubiquitinating enzyme inhibitor that could potentially modulate USP17L29 expression by affecting deubiquitination pathways. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Pyr-41 is a ubiquitin-activating enzyme E1 inhibitor that could potentially modulate USP17L29 expression by inhibiting ubiquitin-dependent protein degradation. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 inhibits the NEDD8-activating enzyme which might affect USP17L29 expression by modulating protein degradation pathways. | ||||||
MLN7243 | 1450833-55-2 | sc-507338 | 5 mg | $340.00 | ||
TAK-243 is a ubiquitin-activating enzyme (UBE1) inhibitor that could potentially modulate USP17L29 expression by inhibiting ubiquitin-dependent protein degradation. | ||||||
NSC 632839 hydrochloride | 157654-67-6 | sc-204138 sc-204138A | 10 mg 50 mg | $119.00 $465.00 | ||
NSC632839 is a ubiquitin isopeptidase inhibitor that might modulate USP17L29 expression by inhibiting deubiquitination processes. | ||||||
UCH-L1 Inhibitor Inhibitor | 668467-91-2 | sc-356182 | 10 mg | $204.00 | 1 | |
UCH-L1 Inhibitor is a ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor that might affect USP17L29 expression by modulating deubiquitination pathways. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
IU1 is a proteasome-associated deubiquitinase inhibitor that might modulate USP17L29 expression by inhibiting deubiquitination processes. | ||||||