UQCRH Activators represent a specific category of chemical compounds that have garnered interest in the field of molecular biology and biochemistry. These activators are designed to modulate the activity of the UQCRH gene, with UQCRH referring to Ubiquinol-Cytochrome c Reductase Core Protein H. This gene encodes a protein that plays a crucial role in the mitochondrial respiratory chain, particularly within Complex III, also known as cytochrome bc1 complex. Complex III is a vital component of the electron transport chain, which is responsible for generating adenosine triphosphate (ATP), the cell's primary source of energy. UQCRH Activators constitute a group of molecules engineered to enhance or stimulate the expression and function of the UQCRH gene, ultimately leading to increased activity of the associated protein.
The mechanism by which UQCRH Activators exert their effects typically involves their interaction with specific regulatory elements within the UQCRH gene, such as promoter regions or enhancer sequences. These interactions facilitate the upregulation of gene transcription, resulting in heightened synthesis of the UQCRH protein. The UQCRH protein is a critical component of Complex III, where it contributes to electron transfer reactions involved in ATP production. As researchers continue to investigate the functions and potential implications of UQCRH activation, the development and refinement of UQCRH Activators hold promise for advancing our understanding of mitochondrial bioenergetics, cellular respiration, and the broader implications of UQCRH in cellular metabolism and energy production, potentially uncovering novel aspects of mitochondrial function and biochemistry.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
As an AMPK activator, metformin may enhance mitochondrial biogenesis and potentially upregulate UQCRH as part of improving mitochondrial efficiency. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate SIRT1, leading to improved mitochondrial function and possibly increased expression of components like UQCRH in response to enhanced energy demand. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
As a PPARγ agonist, pioglitazone might stimulate mitochondrial biogenesis, potentially upregulating UQCRH in tissues sensitive to insulin signaling. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMPK, which can lead to enhanced mitochondrial biogenesis and possibly increased UQCRH expression in response to cellular energy stress. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC, as an antioxidant, may reduce oxidative stress, potentially leading to the upregulation of UQCRH to maintain mitochondrial function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin's antioxidative properties might protect mitochondrial integrity, possibly inducing UQCRH expression as part of a cellular defense mechanism against oxidative damage. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
As an antioxidant and a cofactor in mitochondrial energy metabolism, alpha-lipoic acid might enhance UQCRH expression to support mitochondrial function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG's effects on cellular metabolism and antioxidative defense might indirectly stimulate UQCRH expression as part of enhancing mitochondrial efficiency. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
As a key component in the electron transport chain, supplementation with Coenzyme Q10 might upregulate UQCRH to optimize mitochondrial electron transport. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine can induce autophagy and mitochondrial renewal, potentially leading to increased expression of mitochondrial components like UQCRH. | ||||||