UPIb Activators
UPIb activators encompass a diverse array of chemical compounds that facilitate the enhancement of UPIb activity through intricate signaling pathways. For example, Forskolin and 8-Bromo-cAMP, by increasing intracellular cAMP, activate PKA, which can then phosphorylate various proteins that affect UPIb function, possibly through CREB-mediated gene expression. PMA and Gö6976 manipulate the activity of PKC, leading to potential changes in UPIb activity by modifying its interactions within the cell. Ionomycin and A23187, by elevating intracellular calcium levels, can trigger calcium-dependentUPIb activators encompass a diverse array of chemical compounds that facilitate the enhancement of UPIb activity through intricate signaling pathways. For example, Forskolin and 8-Bromo-cAMP, by increasing intracellular cAMP, activate PKA, which can then phosphorylate various proteins that affect UPIb function, possibly through CREB-mediated gene expression. PMA and Gö6976 manipulate the activity of PKC, leading to potential changes in UPIb activity by modifying its interactions within the cell. Ionomycin and A23187, by elevating intracellular calcium levels, can trigger calcium-dependent kinases, potentially leading to the functional enhancement of UPIb. LY294002 and U0126 disrupt PI3K and MEK1/2 activity, respectively, which may indirectly lead to UPIb activation by shifting signaling dynamics and promoting alternative pathways that support UPIb's role in the cell.
Additionally, SB203580 and PD98059 serve as selective inhibitors of p38 MAPK and MEK, respectively. Their inhibitory actions are thought to create a compensatory upregulation of other signaling pathways that may include the activation of UPIb. Bisindolylmaleimide I and Epigallocatechin gallate (EGCG), through their roles as kinase inhibitors, also contribute to the activation landscape of UPIb. They do this by potentially lifting the inhibition exerted by certain kinases on substrates or pathways that interact with UPIb, thereby promoting its functional activity. Collectively, these UPIb activators, by targeting distinct signaling cascades, facilitate the enhancement of UPIb's role without necessitating a direct increase in its expression or direct stimulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels. This increase in calcium can activate calmodulin-dependent kinases, which may phosphorylate substrates that interact with or modify UPIb function. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. PKA can then phosphorylate proteins that modulate the activity of UPIb, enhancing its functional role in cellular processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter signaling downstream of PI3K. Disruption of PI3K signaling can lead to the activation of alternative pathways that may include the functional activation of UPIb. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 may lead to a compensatory response in related pathways, potentially enhancing the activity of UPIb through crosstalk with other signaling cascades. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that prevents the activation of MAPK/ERK. This may result in the amplification of parallel signaling pathways that can enhance the activity of UPIb. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a selective PKC inhibitor that may lead to activation of UPIb through negative feedback loops or by potentiating other signaling pathways when PKC is inhibited. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor with antioxidant properties. By inhibiting specific kinases, EGCG may indirectly enhance the functional activity of UPIb by reducing competitive signaling and allowing UPIb pathways to be more active. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent proteins and potentially enhancing UPIb function through these calcium signaling pathways. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö6976 is a potent inhibitor of certain PKC isoforms. Inhibition of these PKC isoforms can indirectly enhance the activity of UPIb by shifting the balance of signaling pathways within the cell. | ||||||