UNQ830 Inhibitors
Chemical inhibitors of UNQ830 can interfere with the protein's role in endosomal sorting and trafficking by targeting various stages of the vesicular transport pathway. Bafilomycin A1 inhibits V-ATPases, crucial for vesicular acidification, which is a necessary condition for the proper functioning of UNQ830 in the endocytic pathway. Similarly, Amantadine disrupts endosomal trafficking by changing the pH, which again affects UNQ830's ability to participate in acidification-dependent sorting processes. Monensin, as a carboxylic ionophore, also alters pH gradients and disrupts intracellular transport, further inhibiting the function of UNQ830 in vesicular trafficking.
On the other hand, compounds like Dynasore and MiTMAB directly target the GTPase activity of dynamin, a critical component in the scission of clathrin-coated vesicles from the membrane, thus hindering UNQ830's involvement in the endocytic process. Chlorpromazine and Pitstop 2 obstruct clathrin-mediated endocytosis at different points, with Chlorpromazine disrupting the assembly of clathrin-coated pits and Pitstop 2 blocking the interaction of clathrin's terminal domain with accessory proteins. This disruption to the clathrin-mediated pathway would impede UNQ830's function in vesicular trafficking. Genistein's inhibition of tyrosine kinases can affect endocytic vesicle dynamics, which would also affect UNQ830's role in trafficking. Ikarugamycin, by disrupting clathrin-independent endocytosis, and Filipin III, by binding to cholesterol and disrupting lipid raft domains, can inhibit pathways that UNQ830 may use for its transport functions. Lastly, Nystatin perturbs lipid raft domains by binding ergosterol, and EIPA blocks macropinocytosis, both of which are mechanisms that could inhibit the functional activities of UNQ830.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
This compound inhibits V-ATPases, which are necessary for vesicular acidification. By inhibiting V-ATPases, the endocytic pathway is disrupted. UNQ830, involved in endosomal sorting, would be functionally inhibited as the endosomal sorting and trafficking rely on the acidic environment that V-ATPase helps to maintain. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits dynamin, a GTPase involved in the scission of clathrin-coated vesicles from the membrane. Since UNQ830 is implicated in endocytic pathways, inhibition of vesicle scission would impede the endocytic process, thus functionally inhibiting UNQ830. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is known to disrupt clathrin-mediated endocytosis. By interfering with the assembly of clathrin-coated pits, it would inhibit the pathway that includes vesicular trafficking, where UNQ830 is involved. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is an inhibitor of clathrin terminal domain interaction with accessory proteins, which blocks the formation of clathrin-coated pits. This would disrupt the pathway of vesicular transport that requires clathrin, thereby inhibiting the functional role of UNQ830 in trafficking. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein inhibits tyrosine kinases which can be involved in the regulation of endocytosis. As tyrosine phosphorylation can regulate endocytic vesicle dynamics, this compound could inhibit the functional role of UNQ830 by disrupting its associated signaling. | ||||||
Ikarugamycin | 36531-78-9 | sc-202179 | 500 µg | $185.00 | 4 | |
Ikarugamycin disrupts clathrin-independent endocytosis. As UNQ830 is implicated in endocytic sorting, inhibition of this pathway would impact the protein's functional activity in cellular trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is a carboxylic ionophore that disrupts intracellular transport by altering pH gradients. This would impair vesicular trafficking and thus inhibit the functionality of UNQ830 in its trafficking roles. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Filipin III binds to cholesterol, disrupting lipid raft domains and clathrin-independent endocytosis. This would inhibit UNQ830's function if it is involved in pathways requiring lipid rafts for vesicular transport. | ||||||
1-Adamantylamine | 768-94-5 | sc-251475 sc-251475A | 1 g 25 g | $38.00 $144.00 | ||
Amantadine disrupts endosomal trafficking by altering the pH. Since UNQ830 is involved in endosomal sorting, amantadine would functionally inhibit UNQ830 by hindering its role in the acidification-dependent sorting process. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Nystatin perturbs lipid raft domains by binding to ergosterol, disrupting membrane compartments essential for some endocytic pathways. This would functionally inhibit UNQ830 if it relies on lipid raft-mediated sorting or trafficking. | ||||||