UNC45B Activators
UNC45B activators comprise a suite of chemical compounds that indirectly enhance the protein's functional activity within specific cellular signaling pathways. Forskolin and Sildenafil, by increasing cAMP and cGMP levels respectively, activate PKA and PKG, which are kinases that can phosphorylate substrates also targeted by UNC45B, suggesting an indirect enhancement of UNC45B's role in muscle function and myosin assembly. Caffeine, through its inhibition of phosphodiesterase and subsequent rise in cAMP, also activates PKA, potentially leading to an enhancement of UNC45B's chaperone activity in myosin assembly. The insulin-activatedPI3K/Akt pathway plays a crucial role in glucose metabolism and energy provision for muscle contraction, processes requiring UNC45B's involvement in myosin assembly. Epigallocatechin gallate's inhibition of protein kinases can similarly enhance UNC45B activity by affecting muscle differentiation pathways. Resveratrol's activation of SIRT1 indirectly supports UNC45B by optimizing muscle function and energy homeostasis, which are vital for UNC45B's function.
The PPARδ activator GW501516 and the AMPK activator AICAR both work to enhance metabolic pathways that could increase the demand for UNC45B's activity in muscle fiber maintenance and energy homeostasis. Oligomycin, by inhibiting ATP synthase and increasing the AMP/ATP ratio, indirectly activates AMPK, which may lead to the upregulation of energy-efficient pathways involving UNC45B. Fenofibrate, by activating PPARα, shifts the body's lipid metabolism and energy production to states that require enhanced muscle function, potentially increasing UNC45B's functional demand. Calcium ionophore A23187 raises intracellular calcium levels, essential for muscle contraction and activation of calmodulin-dependent pathways, indirectly enhancing the role of UNC45B in muscle fiber maintenance. Lastly, Cobalt(II) chloride mimics hypoxic conditions, potentially increasing the expression of genes that can enhance UNC45B's role in muscle function and repair during stress conditions. Collectively, these compounds, by targeting various metabolic and signaling pathways, facilitate the enhancement of UNC45B mediated functions without the need for upregulating its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly raises intracellular cAMP levels, which in turn activates PKA (protein kinase A). This activation can lead to phosphorylation of downstream targets that are involved in the same cellular processes as UNC45B, particularly those related to muscle cell function and myosin assembly, thereby enhancing the activity of UNC45B. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterase, thus increasing cAMP levels in the cell. Elevated cAMP activates PKA, which may phosphorylate proteins involved in pathways that UNC45B is part of, enhancing its chaperone-mediated assembly of myosin. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which is involved in glucose uptake and glycogen synthesis. This pathway is crucial for providing the energy required for muscle contraction and protein assembly processes that UNC45B is involved in, potentially enhancing the functional activity of UNC45B in muscle cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate inhibits several protein kinases and has been shown to affect pathways involved in muscle differentiation and function. It may enhance UNC45B activity by modulating kinase-dependent signaling pathways relevant to muscle cell development and myosin assembly. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which is implicated in stress resistance and mitochondrial biogenesis. SIRT1 can indirectly enhance the activity of UNC45B by modulating systems that are dependent on proper muscle function and energy homeostasis, processes in which UNC45B is vital. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516 activates PPARδ, a key regulator of lipid metabolism and muscle fiber type conversion. UNC45B's activity could be enhanced by increased energy expenditure and muscle endurance, leading to greater demands on muscle protein folding and assembly where UNC45B functions. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, a master regulator of cellular energy homeostasis. Through AMPK activation, cellular processes that require energy, including those related to muscle contraction and chaperone activity, are enhanced, potentially increasing the activity of UNC45B in energy-demanding processes. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin inhibits ATP synthase, leading to an increase in cellular AMP/ATP ratio, thereby activating AMPK. Activated AMPK can enhance UNC45B activity indirectly by upregulating energy-efficient pathways that utilize UNC45B for proper muscle function. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate, a PPARα agonist, modulates lipid metabolism and energy production, processes that are essential for muscle function. This metabolic shift may enhance the functional demand on UNC45B in muscle tissue. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 increases intracellular calcium concentration, which is pivotal for muscle contraction and activates calmodulin-dependent pathways. An elevation in calcium can indirectly enhance UNC45B activity by increasing the demand for myosin assembly and muscle fiber maintenance. | ||||||