UIP1 Activators
Ubiquilin-1 (UIP1), also known as UBQLN1, is a protein that in humans is encoded by the UBQLN1 gene. It belongs to the ubiquilin family, which are proteins known to interact with the ubiquitin-proteasome system, a crucial cellular pathway for protein degradation.UIP1 is characterized by several functional domains, including a ubiquitin-like domain at the N-terminus and a ubiquitin-associated domain at the C-terminus. These domains allow UIP1 to bind to both ubiquitinated proteins and components of the proteasome, facilitating the delivery of ubiquitinated proteins to the proteasome for degradation.
UIP1 is also known to interact with presenilin, a protein involved in the production of beta-amyloid, a key player in Alzheimer's disease pathology. This suggests a role for UIP1 in neurodegenerative diseases, although the specifics of this role are still being investigated.Some studies have linked mutations in the UBQLN1 gene to increased risk of Alzheimer's disease and Amyotrophic Lateral Sclerosis (ALS), highlighting the potential importance of UIP1 in neurodegenerative disorders.Moreover, UIP1 may play a role in cancer. It has been suggested that UIP1 can influence the degradation of growth-promoting proteins, thereby potentially affecting cancer progression.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and could indirectly affect HAUS7's role in microtubule dynamics. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, potentially influencing pathways involving HAUS7. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine inhibits microtubule formation, which might impact HAUS7-related microtubule organization. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine inhibits microtubule polymerization, potentially affecting HAUS7's role in spindle assembly. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B is a microtubule stabilizer, potentially influencing HAUS7-mediated microtubule dynamics. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin-5 inhibitor, potentially impacting mitotic spindle dynamics and thus HAUS7 function. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
BI-2536 inhibits Plk1, a protein involved in mitosis, potentially affecting HAUS7's role in spindle assembly. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor, potentially impacting pathways involving HAUS7 in spindle assembly. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a kinesin Eg5 inhibitor, potentially affecting microtubule dynamics and HAUS7 function. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora A kinase inhibitor, which might influence HAUS7's role in mitotic processes. | ||||||