UIP1 Antibody (C-2): sc-393259

UIP1 Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects UIP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UIP1 (C-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UIP1, also known as UCHL5-interacting protein and HAUS augmin-like complex subunit 7, is a 368 amino acid protein encoded by the human HAUS7 gene. UIP1 plays a crucial role in regulating spindle assembly during mitosis, which is essential for accurate chromosome segregation and cell division. UIP1 functions as a key component of the HAUS augmin-like complex, which interacts with the gamma-tubulin ring complex to facilitate microtubule formation necessary for spindle assembly. Additionally, UIP1 binds to UCHL5, a protease that specifically cleaves ′Lys-48′-linked polyubiquitin chains, linking UIP1 to protein degradation pathways. UIP1 localizes to the centrosome during interphase and incorporates into spindle microtubules during mitosis, highlighting UIP1′s importance in maintaining centrosome integrity and proper mitotic function. Detectable UIP1 expression has been observed in various tissues, including the spleen, thymus, testis, ovary, small intestine, and colon, underscoring UIP1′s potential relevance in both normal physiology and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

UIP1 Antibody (C-2) References:

1. Identification of two proteins, S14 and UIP1, that interact with UCH37.  |  Li, T., et al. 2001. FEBS Lett. 488: 201-5. PMID: 11163772
2. A quantitative atlas of mitotic phosphorylation.  |  Dephoure, N., et al. 2008. Proc Natl Acad Sci U S A. 105: 10762-7. PMID: 18669648
3. Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.  |  Wang, B., et al. 2008. Anal Chem. 80: 9526-33. PMID: 19007248
4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.  |  Uehara, R., et al. 2009. Proc Natl Acad Sci U S A. 106: 6998-7003. PMID: 19369198
5. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.  |  Lawo, S., et al. 2009. Curr Biol. 19: 816-26. PMID: 19427217
6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.  |  Mayya, V., et al. 2009. Sci Signal. 2: ra46. PMID: 19690332
7. Expressed STSs and transcription of human Xq28.  |  Esposito, T., et al. 1997. Gene. 187: 185-91. PMID: 9099879

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UIP1 Antibody (C-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-UIP1 Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UIP1 Antibody (C-2) Specifications

Alternate Product Name: UIP1

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: UIP1

Epitope Species: mouse

Product Reactivity/Detection: UIP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for UIP1 Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin