UGT8 Activators
UGT8 Activators represent a diverse group of substances, ranging from fatty acids, vitamins, to phenolic acids. They generally function by enhancing the production of ceramides, which are substrates for UGT8, thereby indirectly increasing the activity of this enzyme. Fatty acids like Arachidonic Acid, Linoleic Acid, Palmitic Acid, Stearic Acid, Oleic Acid, Myristic Acid, Alpha-Linolenic Acid, Valeric Acid, and Butyric Acid can all contribute to the synthesis of ceramides. Ceramides are a type of sphingolipid, and their synthesis involves the condensation of these fatty acids with an amino alcohol. This process creates a ceramide backbone which is a substrate for UGT8, leading to increased enzyme activity.
On the other hand, substances like Caffeic Acid and Rosmarinic Acid exert their influence through different pathways, but they still lead to increased ceramide production. For instance, these phenolic acids could modulate the metabolic pathways involved in sphingolipid synthesis. Lastly, an essential vitamin, Pantothenic Acid, also indirectly activates UGT8 by contributing to the synthesis of coenzyme-A, a crucial co-factor in fatty acid synthesis, thereby increasing ceramide production. This variety of substances and their mechanisms of action demonstrate the complexity and interconnectivity of cellular metabolic processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids of membranes of the body's cells, and is abundant in the brain. It can increase the production of ceramides, which are substrates for UGT8, thereby enhancing its activity. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic Acid is an essential fatty acid. It's involved in the synthesis of arachidonic acid and subsequently ceramides, thus having an indirect activating effect on UGT8. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic acid is a common saturated fatty acid which can be involved in the synthesis of sphingolipids, including ceramides, serving as an indirect activator for UGT8. | ||||||
Stearic Acid | 57-11-4 | sc-203408 sc-203408A sc-203408B | 100 g 1 kg 5 kg | $26.00 $32.00 $117.00 | 1 | |
Stearic Acid is a long-chain saturated fatty acid. It can contribute to the synthesis of ceramides, thereby indirectly increasing the activity of UGT8. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid is a monounsaturated omega-9 fatty acid. It can influence the production of ceramides, indirectly activating UGT8. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Caffeic acid is a hydroxycinnamic acid, a type of phenolic acid. It can indirectly influence the UGT8 activity via modulation of ceramide synthesis. | ||||||
Rosmarinic Acid | 20283-92-5 | sc-202796 sc-202796A | 10 mg 50 mg | $58.00 $109.00 | 4 | |
Rosmarinic Acid is a natural polyphenol antioxidant carboxylic acid. It can influence the production of ceramides, thereby indirectly affecting the activity of UGT8. | ||||||
Myristic Acid | 544-63-8 | sc-205393 sc-205393A sc-205393B | 1 g 5 g 50 g | $31.00 $77.00 $306.00 | 1 | |
Myristic Acid is a common saturated fatty acid that can be involved in the synthesis of sphingolipids including ceramides, thus indirectly activating UGT8. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $38.00 $115.00 | 2 | |
Alpha-Linolenic Acid is a polyunsaturated omega-3 fatty acid. It can be involved in the production of ceramides, thereby indirectly influencing UGT8 activity. | ||||||