UBE1L Activators
UBE1L Activators are chemical compounds that enhance the functional activity of UBE1L, a key enzyme in the ubiquitin-proteasome system. UBE1L Activators enhance the functionality of the E1 ubiquitin-activating enzyme UBE1L, which plays a crucial role in protein degradation via the ubiquitin-proteasome system. The ubiquitin-proteasome system is a complex, multi-step process that marks proteins for degradation by attaching ubiquitin molecules to them in a process known as ubiquitination. UBE1L initiates this process by activating and transferring ubiquitin to E2 ubiquitin-conjugating enzymes. The compounds characterized as UBE1L Activators function by enhancing UBE1L's ubiquitination function indirectly-mostly through inhibition of protein degradation pathways, which increases the demand for the enzyme's activity.
Among UBE1L Activators, proteasome inhibitors such as MG-132, Lactacystin, Bortezomib, and Epoxomicin work by preventing the degradation of ubiquitinated proteins in the proteasome. This action increases the pool of these proteins, leading to a higher demand for UBE1L-mediated ubiquitination, thereby enhancing its enzymatic activity. Autophagy inhibitors, including Chloroquine and 3-Methyladenine, block the autophagic degradation pathway, leading to a similar increase in ubiquitinated proteins and demand for UBE1L's function. Additionally, Leupeptin, a protease inhibitor, and Eeyarestatin I, an inhibitor of endoplasmic reticulum-associated degradation (ERAD), function by preventing the degradation of ubiquitinated proteins. PR-619, a broad-spectrum deubiquitinase inhibitor, enhances UBE1L activity by maintaining the ubiquitinated state of proteins. These diverse compounds all enhance UBE1L activity indirectly, underscoring the enzyme's central role in protein ubiquitination and degradation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. This action increases the pool of these proteins, leading to a higher demand for UBE1L-mediated ubiquitination, thereby enhancing its enzymatic activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
1-Hydroxypyridine-2-thione zinc salt is a metalloproteinase inhibitor. It can affect the degradation of ubiquitinated proteins, leading to an increased demand for UBE1L-mediated ubiquitination, thus indirectly enhancing UBE1L activity. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Lactacystin is a proteasome inhibitor. By preventing the degradation of ubiquitinated proteins, it increases the demand for UBE1L’s ubiquitination activity, enhancing its function. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. By blocking the degradation pathway of ubiquitinated proteins, it increases the need for the ubiquitination activity of UBE1L, indirectly enhancing the functional activity of UBE1L. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Epoxomicin is a proteasome inhibitor. By preventing the degradation of ubiquitinated proteins, it indirectly enhances the activity of UBE1L by increasing the demand for its ubiquitination activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is an autophagy inhibitor that interferes with lysosomal protein degradation. This increases the pool of ubiquitinated proteins, which in turn enhances the ubiquitination activity of UBE1L. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine is an autophagy inhibitor. By blocking the autophagic degradation pathway, it increases the quantity of ubiquitinated proteins, indirectly enhancing the activity of UBE1L by increasing the demand for its ubiquitination function. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
Eeyarestatin I is an inhibitor of endoplasmic reticulum-associated degradation (ERAD). By inhibiting ERAD, it increases the pool of ubiquitinated proteins, indirectly enhancing the activity of UBE1L by increasing the demand for its ubiquitination activity. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $75.00 $184.00 $423.00 | 1 | |
PR 619 is a broad-spectrum deubiquitinase inhibitor. By inhibiting deubiquitination, it indirectly enhances the activity of UBE1L by maintaining the ubiquitinated state of proteins and increasing the demand for its ubiquitination activity. | ||||||