UBCH10 Inhibitors
UBCH10 inhibitors are a class of compounds that specifically target and modulate the activity of the enzyme UBCH10, also known as UBE2C, a member of the ubiquitin-conjugating enzyme family. UBCH10 plays a crucial role in the ubiquitin-proteasome system (UPS), which is responsible for regulating protein degradation within cells. In particular, UBCH10 is involved in the anaphase-promoting complex/cyclosome (APC/C)-mediated ubiquitination of specific proteins that control cell cycle progression, especially during the metaphase-anaphase transition in mitosis. The inhibition of UBCH10 activity can significantly affect the ubiquitination process, thereby altering the timing and regulation of cellular events such as chromosome segregation and mitotic exit.
By modulating the activity of UBCH10, inhibitors of this enzyme can lead to disruptions in the tightly regulated processes of protein turnover and cell cycle control. These inhibitors tend to act by binding to the active site or nearby regions of UBCH10, preventing the transfer of ubiquitin to target substrates. This results in the accumulation of specific proteins that would normally be degraded, affecting the downstream processes that are dependent on protein degradation for their regulation. Given the critical nature of UBCH10 in cell cycle control and protein homeostasis, these inhibitors offer a valuable tool for studying ubiquitination dynamics and the mechanistic roles of UBCH10 in proteostasis and mitotic regulation. Additionally, the structural diversity of UBCH10 inhibitors enables the exploration of various binding modalities and selectivity profiles in the context of ubiquitin-conjugating enzyme function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may reduce UBCH10 expression by inhibiting histone deacetylase, leading to a more open chromatin structure and decreased transcriptional activity of genes including UBCH10. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could potentially lead to hypomethylation of the UBCH10 gene promoter, resulting in downregulation of its expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 could decrease UBCH10 protein levels by inhibiting the proteasome pathway, which may lead to a compensatory reduction in UBCH10 expression due to accumulation of ubiquitinated proteins. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib may decrease the stability of UBCH10 by inhibiting the proteasome, which could potentially lead to a feedback mechanism that reduces UBCH10 expression to maintain cellular homeostasis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide could inhibit UBCH10 protein synthesis by blocking the translocation step in protein elongation, leading to a reduction in UBCH10 protein levels. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to the DNA template near the transcription initiation complex, which could inhibit RNA polymerase movement and decrease UBCH10 mRNA synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin might downregulate UBCH10 protein synthesis by inhibiting mTOR, a central regulator of cell growth and protein translation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 may downregulate UBCH10 expression by inhibiting JNK, which is involved in the control of a wide range of cellular processes, including transcription regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 could lead to a decrease in UBCH10 expression by inhibiting PI3K, which is crucial for numerous cellular functions, including growth factor signaling that can affect gene expression. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 may result in the reduction of UBCH10 expression by inhibiting MEK, which is part of the MAPK/ERK pathway that controls cell division and gene expression. | ||||||