UBAP2 Activators
UBAP2 Activators are a class of compounds that enhance the functional activity of UBAP2 through direct or indirect interactions. For instance, Forskolin, IBMX, BAY 60-6583, Anandamide, Dibutyryl cAMP, and Prostaglandin E2 all work through the cAMP-PKA pathway. They increase the intracellular cAMP levels, leading to the activation of PKA. PKA, in turn, phosphorylates proteins in UBAP2-related pathways, enhancing its functional activity. This class of compounds illustrates how alteration in cAMP levels can directly influence the functional activity of UBAP2.
Other activators like A23187 and Thapsigargin act by increasing intracellular calcium levels, which can activate calcium-dependent kinases that phosphorylate proteins in UBAP2-related pathways. Phorbol 12-myristate 13-acetate (PMA) and Chelerythrine chloride function through the PKC pathway, affecting the phosphorylation state of proteins in UBAP2-related pathways. L-NAME reduces the levels of nitric oxide thereby indirectly leading to enhanced UBAP2 activity. Lastly, Genistein prevents the dephosphorylation of proteins in UBAP2-related pathways, thus maintaining their active state and enhancing the functional activity of UBAP2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 is an A2B adenosine receptor agonist, which is known to increase cAMP levels upon activation. The increased cAMP activates PKA, enhancing the phosphorylation of proteins in UBAP2-related pathways and thus heightening UBAP2 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular levels of calcium. The increased calcium levels can trigger the activation of calcium-dependent kinases that phosphorylate proteins in UBAP2-related pathways, leading to enhanced UBAP2 activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that can activate PKA due to its ability to mimic cAMP. This leads to enhanced phosphorylation of proteins in UBAP2-related pathways, in turn increasing UBAP2 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a known activator of protein kinase C (PKC), which can phosphorylate proteins in UBAP2-related pathways, leading to enhanced UBAP2 activity. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine chloride is a potent, selective, and cell-permeable protein kinase C inhibitor that alters the phosphorylation state of proteins in UBAP2-related pathways. The inhibition of PKC leads to altered phosphorylation state of these proteins, which can enhance UBAP2 activity. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $48.00 $107.00 $328.00 | 45 | |
L-NAME is an inhibitor of nitric oxide synthase, reducing nitric oxide levels, a molecule that can inhibit PKA. Reduced nitric oxide levels can lead to increased PKA activation and enhanced phosphorylation of proteins in UBAP2-related pathways, thereby enhancing UBAP2 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can prevent the dephosphorylation of proteins in UBAP2-related pathways, maintaining their active phosphorylated state and enhancing UBAP2 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 activates the prostaglandin E receptor, leading to elevated cAMP levels. The increased cAMP activates PKA, which enhances the phosphorylation of proteins in UBAP2-related pathways and in turn increases UBAP2 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the SERCA pump, leading to an increase in cytosolic calcium concentration. This can activate calcium-dependent kinases that phosphorylate proteins in UBAP2-related pathways, enhancing UBAP2 activity. | ||||||