U2AF35 Activators
U2AF35 activators are a group of chemicals that modulate the activity of U2AF35, a protein that plays a critical role in the splicing of pre-mRNA in eukaryotic cells. U2AF35, also known as U2AF1, is part of the U2 auxiliary factor complex that recognizes and binds to the polypyrimidine tract adjacent to the 3' splice site of introns. Its role is essential for the proper assembly of the spliceosome, the complex molecular machine that removes introns from pre-mRNA transcripts.
Direct activators of U2AF35 enhance its RNA-binding affinity or its interaction with other spliceosomal components, thereby facilitating the splicing process. This can occur through a conformational change in the U2AF35 protein that increases its ability to recruit U2AF65, another spliceosome component, to the pre-mRNA substrate. Alternatively, a direct activator might stabilize the U2AF35 protein or protect it from proteolytic degradation, thus ensuring a more robust presence in the splicing machinery. Indirect activators may work by upregulating the expression of the U2AF35 gene, thereby increasing the protein's abundance in the cell. They could also modulate post-translational modifications of U2AF35, such as phosphorylation, which can affect its activity and interactions. Furthermore, indirect activators could influence the splicing machinery by affecting the availability or function of cofactors and other proteins that interact with U2AF35 to regulate splice site selection and splicing efficiency.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cyclic AMP (cAMP) levels, triggering the protein kinase A (PKA) pathway. PKA activation leads to phosphorylation of various proteins involved in RNA processing, indirectly influencing U2AF35 function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid interacts with the retinoic acid receptor (RAR), activating the JAK/STAT pathway. STAT proteins regulate transcription of spliceosome components, potentially affecting U2AF35 function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, affecting the Wnt/beta-catenin signaling. Stabilized beta-catenin can influence the transcription of RNA processing genes, indirectly affecting U2AF35. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates the JNK pathway and p38 MAPK, both involved in cellular stress responses. These pathways can influence spliceosome assembly and function, affecting U2AF35. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone modulates the glucocorticoid receptor pathway, which can regulate the transcription of RNA processing genes, thereby influencing U2AF35 function. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates the TRPV1 ion channel, leading to increased calcium influx and activation of calcineurin. Calcineurin can dephosphorylate nuclear factors, indirectly modulating U2AF35 function. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits calcineurin, indirectly affecting U2AF35 function by modulating nuclear factor phosphorylation. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
Tacrolimus inhibits calcineurin, indirectly influencing U2AF35 function through modulation of nuclear factor phosphorylation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 initiates the prostaglandin signaling pathway, which can regulate the expression and function of RNA processing genes, potentially affecting U2AF35. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $374.00 | 4 | |
Leukotriene B4 activates the LTB4 receptor and downstream signaling, which can influence the function of RNA processing genes, potentially affecting U2AF35. | ||||||