Date published: 2026-4-1

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TTP-L Activators

Chemical activators of TTP-L engage various cellular signaling pathways to achieve its activation. Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC), which directly targets TTP-L for phosphorylation, resulting in its activation. Forskolin, by elevating intracellular cAMP levels, activates protein kinase A (PKA) that can also phosphorylate and activate TTP-L. Similarly, Ionomycin, by increasing intracellular calcium concentrations, activates calmodulin-dependent kinases (CaMKs), which are capable of phosphorylating TTP-L, thereby activating it. Thapsigargin works in a related manner to Ionomycin, raising intracellular calcium levels and activating CaMKs, which then phosphorylate and activate TTP-L. Dibutyryl-cAMP, a stable cAMP analogue, activates PKA, leading to the phosphorylation of TTP-L.

Furthermore, Okadaic Acid, through its inhibition of protein phosphatases 1 and 2A, maintains TTP-L in a phosphorylated state, thereby keeping it active. Calyculin A also inhibits protein phosphatases, ensuring TTP-L remains phosphorylated and active. Zinc Pyrithione induces oxidative stress that activates stress-activated protein kinases (SAPKs), which in turn phosphorylate and activate TTP-L. Anisomycin stimulates the MAP kinase pathway, which activates kinases that phosphorylate TTP-L. Phosphatidic Acid activates the mTOR signaling pathway, which is known to phosphorylate and activate TTP-L. Epigallocatechin Gallate triggers the activation of AMP-activated protein kinase (AMPK), which upon activation can lead to the phosphorylation and consequent activation of TTP-L. Bisphenol A disrupts normal kinase signaling pathways, which can lead to the aberrant phosphorylation and activation of TTP-L. Each of these chemicals, by affecting specific kinases or phosphatases, ensures the activation of TTP-L through direct phosphorylation events.

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Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates protein kinase C (PKC), which in turn directly phosphorylates TTP-L, leading to its activation.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$78.00
$270.00
80
(4)

Ionomycin increases intracellular calcium levels, leading to the activation of calmodulin-dependent kinases (CaMKs) that can phosphorylate and activate TTP-L.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin raises intracellular calcium levels, which can activate CaMKs, leading to phosphorylation and activation of TTP-L.

Dibutyryl-cAMP

16980-89-5sc-201567
sc-201567A
sc-201567B
sc-201567C
20 mg
100 mg
500 mg
10 g
$47.00
$136.00
$492.00
$4552.00
74
(7)

Dibutyryl-cAMP, as a stable analogue of cAMP, activates PKA which phosphorylates and activates TTP-L.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$291.00
$530.00
$1800.00
78
(4)

Okadaic Acid inhibits protein phosphatases 1 and 2A, leading to sustained phosphorylation and activation of TTP-L.

Calyculin A

101932-71-2sc-24000
sc-24000A
10 µg
100 µg
$163.00
$800.00
59
(3)

Calyculin A inhibits protein phosphatases, which keeps TTP-L in a phosphorylated and active state.

Zinc

7440-66-6sc-213177
100 g
$48.00
(0)

Zinc Pyrithione induces oxidative stress, which can activate stress-activated protein kinases (SAPKs) that phosphorylate and activate TTP-L.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$99.00
$259.00
36
(2)

Anisomycin activates the MAP kinase pathway, leading to activation of kinases that phosphorylate and activate TTP-L.

Phosphatidic Acid, Dipalmitoyl

169051-60-9sc-201057
sc-201057B
sc-201057A
100 mg
250 mg
500 mg
$106.00
$244.00
$417.00
(1)

Phosphatidic Acid stimulates the mTOR signaling pathway, which can lead to the phosphorylation and activation of TTP-L.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

Epigallocatechin Gallate activates AMP-activated protein kinase (AMPK), which can lead to downstream activation of TTP-L through phosphorylation.