TTC5 Activators
TTC5, or Tetratricopeptide Repeat Domain 5, is a protein encoded by the TTC5 gene in humans and has been implicated in a variety of cellular functions. This protein is characterized by its tetratricopeptide repeat (TPR) motifs, which are known to mediate protein-protein interactions and are involved in complex cellular processes such as cell cycle regulation and signal transduction. The precise biological roles of TTC5 are not fully delineated; however, it is understood that the protein can play a significant part in cellular homeostasis and has been associated with cellular responses to stress. TTC5 expression levels may vary across different cell types and can be influenced by a range of intracellular and extracellular stimuli.
The expression of TTC5 can be hypothesized to be induced or upregulated by various chemical compounds that interact with cellular signaling pathways. For instance, retinoic acid, a derivative of vitamin A, could stimulate TTC5 expression by activating retinoid receptors, which then bind to DNA sequences in the TTC5 promoter region, enhancing gene transcription. Similarly, 5-Azacytidine, which inhibits DNA methylation, could lead to the upregulation of TTC5 by increasing the transcriptional accessibility of its gene promoter. Compounds like Trichostatin A and Sodium butyrate, known histone deacetylase inhibitors, may also increase TTC5 expression by inducing a more relaxed chromatin structure around the TTC5 gene, allowing for greater transcriptional activity. Moreover, signaling molecules such as Beta-estradiol could bind to estrogen receptors that interact with the TTC5 gene promoter to stimulate transcription
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could initiate transcriptional activation of TTC5 by binding to retinoic acid receptors, which may then bind to retinoid response elements in the TTC5 gene promoter, potentially stimulating its transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could prompt hypomethylation and consequently upregulate TTC5 expression by enhancing the accessibility of transcription factors to the TTC5 gene promoter. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This compound may promote acetylation of histones associated with the TTC5 gene, leading to an open chromatin conformation and facilitating transcriptional machinery access, thereby upregulating TTC5. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin could elevate intracellular cAMP, activating protein kinase A (PKA) and leading to the activation of transcription factors that increase TTC5 gene transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate's inhibition of histone deacetylase can lead to enhanced acetylation of histones near the TTC5 gene, potentially creating a transcriptionally active chromatin state that upregulates TTC5 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol might bind to estrogen receptors that interact with estrogen response elements in the TTC5 gene promoter, leading to increased transcription and upregulation of TTC5. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can activate glucocorticoid receptors, which may bind to glucocorticoid response elements within the TTC5 promoter region, stimulating an increase in TTC5 transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
By inhibiting GSK-3, lithium chloride could stimulate the Wnt signaling pathway, potentially leading to downstream transcriptional upregulation of TTC5 through β-catenin stabilization. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin may downregulate mTOR activity, which could lead to a compensatory upregulation of TTC5 expression as the cell attempts to rebalance protein synthesis and cell growth pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin might activate transcription factors such as NF-kB, which could bind to their respective response elements in the TTC5 gene promoter, leading to increased TTC5 transcription. | ||||||