TTC3 Inhibitors
TTC3 inhibitors belong to a category of chemical compounds designed to selectively target and modulate the activity of the Tetratricopeptide repeat domain 3 (TTC3) protein. TTC3 is a member of the tetratricopeptide repeat (TPR) protein family, known for its unique structural motif composed of repetitive helical elements. These TPR motifs are involved in protein-protein interactions and serve as scaffolds for the assembly of multi-protein complexes. TTC3, in particular, plays a crucial role in various cellular processes by acting as a chaperone or co-chaperone, assisting in protein folding, stability, and transport within the cell.
Inhibiting TTC3 can be of great significance in scientific research as it allows for the investigation of its role in various cellular pathways and protein-protein interactions. By modulating TTC3 activity, researchers can gain insights into the regulatory networks governing processes such as protein homeostasis, intracellular trafficking, and quality control. Additionally, understanding the interactions of TTC3 with its binding partners can uncover its involvement in signal transduction, gene expression, and other fundamental cellular functions. Therefore, TTC3 inhibitors serve as valuable tools in elucidating the intricate molecular mechanisms that underlie these cellular processes, ultimately contributing to a better comprehension of cell biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds DNA and disrupts mRNA synthesis, potentially diminishing TTC3 expression by inhibiting RNA polymerase. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Inhibits RNA polymerase II, likely reducing transcription levels of TTC3 among other nuclear-encoded genes. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Blocks eukaryotic peptide elongation, which may indirectly decrease TTC3 levels by inhibiting overall protein synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Binds to FKBP12 and inhibits mTOR, which could influence TTC3 expression by modulating protein synthesis pathways. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A uracil analog that interferes with nucleotide synthesis, potentially affecting TTC3 mRNA synthesis. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Binds to DNA and can interfere with transcription factor binding, possibly reducing TTC3 gene expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Known to inhibit transcription broadly, could decrease TTC3 expression as part of its wider inhibitory effects on gene expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Interferes with lysosomal acidification and autophagy, potentially modulating TTC3 expression indirectly through cellular stress pathways. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor that might indirectly affect TTC3 levels by altering protein degradation pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A reversible proteasome inhibitor that could impact TTC3 expression by altering the degradation of regulatory proteins. | ||||||