TTC28 Inhibitors
Chemical inhibitors of TTC28 include a variety of compounds that interfere with microtubule dynamics, an essential component of cell division and cytoskeletal organization, processes with which TTC28 is associated. Palbociclib, for example, can impede TTC28's role in cell division by inhibiting cyclin-dependent kinases 4 and 6, which are crucial for cell cycle progression. Similarly, Vincristine can inhibit TTC28's function by preventing microtubule formation, which is critical for mitotic spindle assembly and thus could disrupt TTC28's role in cell division. Paclitaxel, by stabilizing microtubules, can interfere with the proper disassembly required for cell cycle progression, thereby indirectly inhibiting TTC28. Nocodazole and Colchicine both inhibit microtubule polymerization, which could hamper TTC28's potential role in stabilizing these cellular structures.
Further, Podophyllotoxin can inhibit TTC28's function by targeting tubulin polymerization, which is necessary for microtubule assembly and cell division. Eribulin, by inhibiting the growth phase of microtubule dynamics, can disrupt cellular processes that TTC28 may influence. Vinblastine, through its binding to tubulin, can inhibit microtubule formation, potentially affecting TTC28's role in cellular architecture and division processes. Monastrol, an inhibitor of kinesin Eg5, can indirectly inhibit TTC28's function in mitosis by disrupting spindle fiber mechanics essential for chromosome segregation. Griseofulvin, Thiabendazole, and Albendazole are all microtubule-interfering agents that can inhibit TTC28 by binding to tubulin or inhibiting microtubule polymerization, thus disrupting the microtubule movements and assembly. These actions can indirectly inhibit TTC28's function if it is involved in processes that require intact microtubules, such as vesicle transport, intracellular organization, and cell division. The disruption of these microtubule-dependent processes by these chemicals can thereby inhibit the proper functioning of TTC28 within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
As an inhibitor of cyclin-dependent kinases (CDKs) 4 and 6, Palbociclib can disrupt cell cycle progression which TTC28 is believed to be involved in. Inhibition of CDKs can thus impede TTC28's role in cell division. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and as a result can aberrantly regulate microtubule dynamics. TTC28 is potentially involved in microtubule assembly, thus paclitaxel may interfere with TTC28's role by preventing proper microtubule disassembly. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization. Considering TTC28's putative association with microtubules, nocodazole can indirectly inhibit TTC28's function by disassembling microtubules. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization. By disturbing microtubule dynamics, TTC28's associated functions could be indirectly inhibited due to its potential role in microtubule stabilization. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization. As TTC28 may interact with microtubules for proper cell division, podophyllotoxin's action on tubulin may indirectly inhibit TTC28's function in the cell. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of the microtubule dynamics. Since TTC28 is implicated in microtubule-dependent processes, its function could be indirectly inhibited by eribulin's stabilization of microtubules. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule formation. TTC28's function, potentially related to microtubule dynamics, could be indirectly inhibited by the prevention of microtubule assembly. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is an inhibitor of kinesin Eg5 which is essential for spindle fiber formation during mitosis. Since TTC28 is thought to be involved in cell division, inhibition of spindle fiber mechanics can indirectly inhibit TTC28's function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin. This can indirectly inhibit TTC28's function if TTC28 is involved in cell cycle progression that relies on microtubule dynamics. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole inhibits microtubule polymerization. If TTC28's function is related to microtubule assembly, the inhibition of polymerization could result in indirect inhibition of TTC28. | ||||||