TSR-1 Inhibitors
Chemical inhibitors of TSR-1 encompass a variety of compounds that can impact different signaling pathways which are essential for TSR-1 activity. Haloperidol, by targeting G-protein coupled receptors (GPCRs), inhibits downstream signaling pathways that are potentially important for TSR-1 regulatory interactions. Similarly, both Wortmannin and LY294002 are inhibitors of phosphoinositide 3-kinases (PI3K), leading to disruption of PI3K/AKT pathway signaling, which is likely to be crucial for TSR-1 function. Rapamycin, an inhibitor of the mTOR kinase, can also reduce the activity of proteins downstream of the PI3K/AKT/mTOR pathway, which may be necessary for the activity of TSR-1.
Further, the MEK/ERK pathway is another target for the regulation of TSR-1 activity, with PD98059 and U0126 acting as inhibitors of different components of this pathway, potentially decreasing the activity of proteins that function downstream. SB203580, which targets p38 MAP kinase, and SP600125, an inhibitor of c-Jun N-terminal kinase (JNK), can interfere with stress response and apoptosis signaling pathways, respectively. This interference can disrupt processes that contribute to TSR-1 activity. Inhibition of Rho-associated protein kinase (ROCK) by Y-27632 can affect cell motility and structure-related signaling, which may be involved in TSR-1 regulation. Additionally, Go6983 and GF109203X, both inhibitors of protein kinase C (PKC), can disrupt PKC-mediated signaling pathways that could be critical for TSR-1 function. Lastly, PP2, an inhibitor of Src family kinases, can impact cell growth and differentiation signaling pathways, which are important for the function of TSR-1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
Haloperidol, an antipsychotic agent, inhibits the downstream signaling pathways of G-protein coupled receptors, which could lead to functional inhibition of TSR-1 by limiting its potential regulatory interactions with GPCR-mediated signaling processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which play a crucial role in signaling pathways. Inhibition of PI3K can disrupt downstream signaling events that could be necessary for TSR-1 function, thereby inhibiting TSR-1's activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key kinase in the PI3K/AKT/mTOR pathway, which is often involved in protein synthesis and cell growth. By inhibiting mTOR, Rapamycin could reduce the activity of downstream proteins that may be essential for TSR-1 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor, which would inhibit the PI3K/AKT pathway and subsequently inhibit downstream proteins and processes that are potentially critical for TSR-1 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of the MEK/ERK pathway, which is involved in cell proliferation and survival. Inhibition of this pathway can lead to a decrease in the activity of downstream proteins that may be necessary for the functional activity of TSR-1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. The p38 MAPK pathway is involved in stress responses and apoptosis. Inhibition of this pathway can disrupt processes that may contribute to TSR-1 activity or its regulatory mechanisms. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is implicated in cell stress and apoptosis signaling pathways. By inhibiting JNK, this compound could inhibit signaling cascades that may indirectly involve TSR-1 function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits the Rho-associated protein kinase (ROCK), which plays a significant role in cell motility and structure. Through the inhibition of ROCK, Y-27632 could interfere with cell signaling pathways that are potentially involved in the functional regulation of TSR-1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream regulators of the ERK pathway. By inhibiting MEK1/2, U0126 can disrupt the ERK signaling pathway and thereby decrease functions of downstream proteins and processes that may be essential for the functional activity of TSR-1. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go6983 is a broad-spectrum protein kinase C (PKC) inhibitor. PKC plays roles in various signaling pathways, including those that regulate cell proliferation and death. Inhibition of PKC can disrupt signaling that might be critical for TSR-1 function. | ||||||