TSPYL4 Activators
The group of chemicals identified for TSPYL4 activation is intricately linked with gene regulation, chromatin modification, and cellular stress response pathways. For instance, Sodium Butyrate is a HDAC inhibitor that can lead to chromatin decondensation, creating a more permissive state for TSPYL4 gene transcription. Similarly, Zebularine, as a DNA methyltransferase inhibitor, can enable gene expression, thus upregulating TSPYL4. Resveratrol and Anacardic Acid target SIRT1 and p300 respectively, which are known modulators of gene silencing and acetylation, thereby influencing TSPYL4 expression.
Genistein and Indole-3-Carbinol activate ER and AhR signaling pathways, which have been associated with TSPYL4 upregulation. Sulforaphane activates NRF2, which controls various stress genes that lead to TSPYL4 activation. Curcumin inhibits NF-κB, lifting the repressive effects this molecule has on TSPYL4. Lastly, LY294002 inhibits the PI3K/AKT pathway, a known negative regulator of TSPYL4, effectively leading to its activation. These chemicals collectively indicate the diversity of cellular processes that can be targeted to activate TSPYL4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates SIRT1, a gene silencing modulator, that could lead to upregulation of TSPYL4. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
HDAC inhibitor promoting chromatin loosening, increasing TSPYL4 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another HDAC inhibitor that upregulates TSPYL4 via chromatin modification. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Inhibits p300 histone acetyltransferase, allowing increased TSPYL4 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Activates ER pathways, known to associate with TSPYL4 upregulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
NRF2 activator, known to control various stress genes, leading to TSPYL4 upregulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Inhibits NF-κB, a repressor of TSPYL4, thereby leading to TSPYL4 activation. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Activates AhR signaling, which is associated with TSPYL4 upregulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K/AKT pathway, known to have negative regulation on TSPYL4, leading to its activation. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
DNA methyltransferase inhibitor, upregulates TSPYL4 by promoting gene expression. | ||||||