TSPAN19 Inhibitors
TSPAN19 inhibitors are a class of compounds designed to disrupt the activation and cellular functions of the TSPAN19 protein. These inhibitors target specific signaling pathways associated with TSPAN19, hindering its involvement in critical cellular processes. Lapatinib and Erlotinib, for example, selectively inhibit EGFR, impacting downstream cascades crucial for TSPAN19 activation. Sorafenib, on the other hand, acts as a multi-kinase inhibitor, disrupting MAPK pathways essential for TSPAN19-mediated events.
Other inhibitors like PP2, U0126, and Wortmannin target kinases involved in TSPAN19-related signaling pathways, preventing key phosphorylation events. Dasatinib, a Src family kinase inhibitor, interferes with TSPAN19 by disrupting Src kinase-mediated activation processes. LY294002 and Gefitinib specifically target PI3K and EGFR, respectively, obstructing pathways crucial for TSPAN19 activation. SB203580, SP600125, and SB431542 focus on p38 MAPK, JNK, and TGF-β signaling pathways, respectively, disrupting TSPAN19-related cellular functions. Overall, TSPAN19 inhibitors present a diverse array of compounds targeting specific molecular events to impede the activation and cellular functions of the TSPAN19 protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $420.00 | 32 | |
Lapatinib, a tyrosine kinase inhibitor, interferes with TSPAN19 activation by targeting the EGFR and HER2 receptors, suppressing downstream signaling pathways. It hinders the phosphorylation cascades essential for TSPAN19 activity. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib impedes TSPAN19 function by inhibiting multiple kinases in the MAPK signaling pathway. Its broad-spectrum kinase inhibition disrupts the downstream events, affecting TSPAN19-related pathways and ultimately suppressing the protein's activation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2, a Src family kinase inhibitor, disrupts TSPAN19 signaling by preventing phosphorylation events. It specifically targets Src family kinases, which play a role in TSPAN19 activation pathways, leading to the inhibition of TSPAN19-related cellular processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126, a MEK inhibitor, interferes with TSPAN19 by blocking the MEK/ERK signaling cascade. By inhibiting MEK, it disrupts the transmission of signals essential for TSPAN19 activation, thereby impeding the protein's involvement in cellular processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, disrupts TSPAN19 pathways associated with PI3K signaling. It hampers the activation of downstream effectors, impeding the cellular events facilitated by TSPAN19 and contributing to its inhibition. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib, a BCR-ABL and Src family kinase inhibitor, disrupts TSPAN19 activation by targeting Src kinases. It interferes with the phosphorylation events crucial for TSPAN19-related signaling pathways, leading to the inhibition of TSPAN19-dependent cellular processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, hinders TSPAN19 by targeting the PI3K/Akt signaling pathway. It disrupts the phosphorylation cascades necessary for TSPAN19 activation, impeding the protein's participation in cellular processes influenced by the PI3K/Akt pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, interferes with TSPAN19 activation by disrupting the p38 MAPK signaling pathway. It inhibits the downstream events crucial for TSPAN19-related functions, contributing to the suppression of TSPAN19-mediated cellular processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, disrupts TSPAN19 pathways associated with the JNK signaling cascade. By inhibiting JNK, it hampers the activation of downstream effectors, impeding the cellular events facilitated by TSPAN19 and contributing to its inhibition. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $87.00 $135.00 $293.00 $505.00 $3827.00 | 42 | |
Erlotinib, an EGFR inhibitor, interferes with TSPAN19 activation by targeting the EGFR receptor. It suppresses the downstream signaling events essential for TSPAN19 activity, thereby inhibiting TSPAN19-mediated cellular processes influenced by EGFR-related pathways. | ||||||