TSPAN1 Activators
TSPAN1 Activators refers to a specific class of chemical compounds that exhibit the ability to modulate the activity of the transmembrane 4 superfamily member 1 (TSPAN1) protein. TSPAN1, also known as tetraspanin-1, is a member of the tetraspanin family of proteins that play crucial roles in various cellular processes, including cell adhesion, migration, and signal transduction. These activators are designed to interact with TSPAN1, eliciting changes in its conformation or facilitating its association with other cellular components. The modulation of TSPAN1 activity holds significant implications for the regulation of cellular functions and processes.
Chemically, TSPAN1 Activators may possess specific structural features that enable them to interact selectively with TSPAN1. This interaction can lead to downstream effects within the cell, influencing intracellular signaling cascades or altering the organization of membrane protein complexes. The discovery and development of TSPAN1 Activators highlight the ongoing efforts in chemical biology to understand and manipulate cellular processes at the molecular level. Further research in this area may elucidate the precise mechanisms by which these activators influence TSPAN1 function, contributing to our broader understanding of tetraspanin biology and offering insights into the development of novel tools for studying cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which in turn can enhance the clustering of tetraspanins and their associated proteins, thereby potentially enhancing the functional activity of TSPAN1 by promoting its role in signal transduction and cellular adhesion. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol is crucial for the integrity of lipid rafts, and tetraspanins are known to associate with these rafts. By maintaining raft integrity, cholesterol can enhance the functional activity of TSPAN1 in these microdomains, affecting cellular signaling and adhesion. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA activates G protein-coupled receptors (GPCRs), leading to cellular responses that involve tetraspanins. Through GPCR signaling, LPA could indirectly enhance the functional activity of TSPAN1 by influencing its role in cellular processes like migration and proliferation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P binds to and activates S1P receptors, which are GPCRs that can interact with tetraspanins. S1P receptor activation can enhance the functional activity of TSPAN1 by facilitating its involvement in cellular signaling related to angiogenesis and vascular stability. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 increases intracellular calcium levels, which can activate calcium-dependent pathways interacting with tetraspanins. The rise in calcium levels can enhance the functional activity of TSPAN1 by promoting its participation in cell adhesion and signaling. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP is a secondary messenger that can activate PKA, leading to phosphorylation events affecting tetraspanins. By modulating PKA activity, cAMP can enhance the functional activity of TSPAN1 by influencing its role in signaling pathways and possibly its distribution within the plasma membrane. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate lipid raft composition and influence signaling pathways associated with tetraspanins. By altering the lipid environment, curcumin can enhance the functional activity of TSPAN1 as it may affect the organization and function of tetraspanin-enriched microdomains. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Glutathione maintains a reducing environment in the cell, which can affect disulfide bonds within tetraspanins. By influencing the redox state, glutathione can enhance the functional | ||||||