TrxR1 Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin is a distinctive compound known for its selective inhibition of thioredoxin reductase 1 (TrxR1), a key enzyme in redox regulation. Its unique molecular structure allows for specific interactions with the enzyme's active site, disrupting electron transfer processes. This interference alters cellular redox homeostasis, leading to oxidative stress. Chaetocin's reactivity is influenced by its ability to form stable adducts, which modulate its kinetic behavior in biochemical pathways. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin inhibits TRXR1 by forming a stable complex with the enzyme's selenocysteine residue, disrupting its activity and leading to oxidative stress and apoptosis in cancer cells. | ||||||
Aureothin | 2825-00-5 | sc-202478 sc-202478A | 1 mg 5 mg | $309.00 $800.00 | 1 | |
Aureothin is a notable compound recognized for its interaction with thioredoxin reductase 1 (TrxR1), where it acts as a potent inhibitor. Its unique structural features facilitate specific binding to the enzyme, disrupting critical electron transfer mechanisms. This disruption influences cellular redox balance, promoting oxidative stress. Aureothin's reactivity is characterized by its ability to engage in dynamic molecular interactions, affecting its kinetic profile and stability in various biochemical environments. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen is a covalent inhibitor of TRXR1 that binds to the selenocysteine active site, preventing the reduction of thioredoxin and causing ROS accumulation and cell death. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits TRXR1 by directly interacting with its active site, disrupting its redox function and promoting apoptosis in cancer cells. | ||||||
PX 12 | 141400-58-0 | sc-358518 sc-358518A | 10 mg 50 mg | $133.00 $505.00 | 9 | |
PX-12 inhibits TRXR1 through a reversible reaction, leading to the accumulation of ROS and induction of apoptosis in cancer cells. | ||||||
Bismuth(III) subsalicylate | 14882-18-9 | sc-227416 | 100 g | $30.00 | ||
Bismuth subsalicylate inhibits TRXR1 by forming a complex with the enzyme's selenocysteine residue, impairing its redox function and inducing oxidative stress. | ||||||
Lapachol | 84-79-7 | sc-252947 | 250 mg | $94.00 | 1 | |
Lapachol inhibits TRXR1 by interfering with its active site, disrupting thioredoxin reduction, and inducing apoptosis in cancer cells. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib indirectly inhibits TRXR1 by targeting multiple signaling pathways, leading to TRXR1 downregulation and increased oxidative stress in cancer cells. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $88.00 $316.00 | 22 | |
Tanshinone IIA inhibits TRXR1 by binding to its active site and inhibiting thioredoxin reduction, leading to ROS accumulation and apoptosis. | ||||||