Trmt2b Activators
Chemical activators of tRNA methyltransferase 2 homolog B play a crucial role in enhancing the protein's function by providing necessary substrates and cofactors. S-Adenosylmethionine (SAMe) is the primary methyl donor in methylation reactions facilitated by this enzyme. Its availability is pivotal for the activation of tRNA methyltransferase 2 homolog B, as it provides the essential methyl groups needed for the methylation of tRNA molecules. Betaine, a derivative of choline, serves as an alternative source of methyl groups, contributing to the generation of SAMe, thus supporting the methylation capacity of the enzyme. Folic acid is integral to this process, as it is involved in the one-carbon metabolism pathway, which is essential for the formation of SAMe. By contributing to this pathway, folic acid ensures a steady supply of methyl donors for the activation of tRNA methyltransferase 2 homolog B.
Cobalamin (Vitamin B12) and Methionine are both key components in the synthesis of SAMe. Cobalamin acts as a cofactor in the conversion of homocysteine to methionine, which is then transformed into SAMe. Methionine itself provides a direct source for SAMe production, bolstering the enzyme's activity. Riboflavin is necessary for the synthesis of flavin adenine dinucleotide (FAD), which is involved in the production of methyl donors for SAMe generation. Pyridoxal phosphate (Vitamin B6) influences homocysteine metabolism, which is closely linked to the synthesis of SAMe, thereby enabling the activation of tRNA methyltransferase 2 homolog B. Additionally, minerals such as magnesium and zinc are essential for the enzyme's activity; magnesium is a cofactor required for the catalytic action of the enzyme, while zinc may be necessary for maintaining the structural integrity of the protein and facilitating its function. Nicotinamide adenine dinucleotide (NAD+) and Thiamine pyrophosphate are also involved in metabolic pathways that generate methyl donor molecules, thereby supporting the overall methylation process catalyzed by tRNA methyltransferase 2 homolog B.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
S-Adenosylmethionine (SAMe) donates methyl groups required for methylation reactions. As tRNA methyltransferase 2 homolog B is involved in tRNA methylation, SAMe provides the essential substrate for the activation of its methyltransferase activity. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $30.00 $40.00 $55.00 $160.00 $330.00 $580.00 | 2 | |
Betaine acts as a methyl donor in the methionine cycle and can provide additional methyl groups for S-Adenosylmethionine synthesis, thereby supporting the methylation capacity of tRNA methyltransferase 2 homolog B. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic acid contributes to the one-carbon metabolism pathway which is crucial for the generation of S-Adenosylmethionine, the methyl donor substrate for tRNA methyltransferase 2 homolog B, hence supporting its methylation activity. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Cobalamin (Vitamin B12) is a cofactor in the synthesis of methionine from homocysteine, which is a precursor for S-Adenosylmethionine. This contributes to the overall activation of tRNA methyltransferase 2 homolog B by ensuring substrate availability. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $40.00 $110.00 $515.00 | 3 | |
Riboflavin (Vitamin B2) is integral for the synthesis of flavin adenine dinucleotide (FAD), which is involved in the production of 5-methyltetrahydrofolate, a key methyl donor for the generation of S-Adenosylmethionine, thereby activating tRNA methyltransferase 2 homolog B. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $102.00 | ||
Pyridoxal phosphate (Vitamin B6) is a cofactor in homocysteine metabolism, influencing the synthesis of S-Adenosylmethionine. Enhanced availability of this cofactor can activate tRNA methyltransferase 2 homolog B by increasing methyl group supply. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
Methionine is directly involved in the methylation cycle as a precursor to S-Adenosylmethionine. By increasing the pool of methionine, the activation of tRNA methyltransferase 2 homolog B can be supported due to more substrate being available for methylation reactions. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $32.00 $36.00 $51.00 | 1 | |
Choline is a key component in the methionine metabolism pathway. It can be oxidized to betaine, which in turn contributes to the methylation cycle by providing methyl groups, thus activating tRNA methyltransferase 2 homolog B. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a known cofactor for various enzymes and is required for the structural integrity of many proteins. Its role as a cofactor may extend to tRNA methyltransferase 2 homolog B, where it could activate the enzyme's catalytic function. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+, in its role as a cofactor, is essential for many enzymatic reactions, including those in the methylation cycle that could lead to the activation of tRNA methyltransferase 2 homolog B through an increase in available methyl donors for S-Adenosylmethionine. | ||||||