TRIM74 Activators
TRIM74 activators pertain to a class of chemical compounds that interact with the tripartite motif-containing protein 74 (TRIM74), a member of the TRIM protein family. The TRIM proteins are characterized by the presence of a conserved tripartite motif composed of a RING (Really Interesting New Gene) domain, one or two B-box domains, and a coiled-coil region, which together facilitate protein-protein interactions and are implicated in various cellular processes. TRIM74 activators are specialized molecules that specifically bind to and modulate the activity of TRIM74. The precise mechanism by which these activators exert their influence can vary, but typically involves promoting the stabilization, dimerization, or conformational changes of the TRIM74 protein, thereby augmenting its intrinsic functional activity. The molecular design of TRIM74 activators is often based on an understanding of the structural biology of TRIM74, including the key domains and the active sites essential for its activity.
The chemical structures of TRIM74 activators are diverse, reflecting the complexity of the protein they target. They may be small organic molecules, peptides, or other types of chemical agents tailored to interact with specific regions of TRIM74. The interaction between a TRIM74 activator and the protein may enhance the protein's interaction with other cellular components, or it may influence the protein's stability within the cellular environment. Researchers studying TRIM74 activators often employ a variety of methods to ascertain the efficacy and specificity of these compounds, including biochemical assays, structural analysis through techniques such as X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy, and cellular assays to observe the activator's effect on TRIM74 within a biological context. The development of TRIM74 activators can involve iterative processes of synthesis and testing, with modifications to the chemical structure made in response to empirical findings regarding the interaction between the compound and the TRIM74 protein.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Cyclic AMP (cAMP) is a secondary messenger that is crucial in many biological processes. It activates protein kinase A (PKA), which then phosphorylates target proteins. In the context of TRIM74, increased cAMP levels could facilitate PKA-mediated phosphorylation of substrates that interact with TRIM74, leading to its functional activation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is an essential trace element known to act as a cofactor for various proteins. TRIM74, like other TRIM family proteins, may require zinc ions for its E3 ubiquitin ligase activity. The presence of zinc ions could therefore stabilize the TRIM74 structure and enhance its enzymatic function. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese ions are co-factors for many enzymes. If TRIM74 has E3 ubiquitin ligase activity that requires divalent metal ions for optimal function, manganese could act to enhance TRIM74’s enzymatic activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is a coenzyme in redox reactions and also serves as a substrate for ADP-ribosylation reactions. ADP-ribosylation can modify protein function; therefore, NAD+ may indirectly enhance TRIM74 activity through ADP-ribosylation of proteins that interact with or regulate TRIM74. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular levels of cAMP. This rise in cAMP potentially enhances the activity of TRIM74 by activating PKA, which may phosphorylate and activate proteins that interact with or regulate TRIM74. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol Hydrochloride is a beta-adrenergic agonist that increases cAMP levels in cells, leading to PKA activation. This can indirectly enhance TRIM74 activity by phosphorylating proteins in pathways associated with TRIM74 function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can lead to the activation of pathways that may involve TRIM74, thus indirectly enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC can lead to downstream signaling events that enhance TRIM74 activity if TRIM74 is part of PKC-regulated pathways. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid can integrate into cell membranes and affect their fluidity, which can influence membrane-associated signaling pathways. If TRIM74 is associated with such pathways, oleic acid may indirectly enhance its activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, leading to increased cytosolic calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, potentially enhancing the activity of TRIM74 if it is involved in these pathways. | ||||||