TRIM30A Activators
TRIM30A Activators represent a collection of compounds that, through their effects on various cellular signaling pathways, can indirectly enhance the functional activity of TRIM30A. TRIM30A, being a member of the tripartite motif (TRIM) family, is involved in ubiquitination processes, immune response regulation, and potentially other cellular signaling pathways. The compounds listed are not direct activators of TRIM30A but rather influence the cellular environment in a manner that could logically result in the enhancement of TRIM30A's activity. They operate through distinct mechanisms of action, such as the elevation of secondary messengers (e.g., cAMP, calcium), inhibition of phosphatases leading to an increase in protein phosphorylation, or inhibition of proteasomal degradation, which could increase the pool of proteins available for TRIM30A-mediated ubiquitination.
The biochemical and cellular pathways influenced by these compounds intersect with processes that TRIM30A may regulate or be a part of. For example, compounds that alter kinase activity (e.g., Forskolin, PMA) or phosphatase activity (e.g., Okadaicacid, Calyculin A) may modulate the phosphorylation state of proteins that are substrates for TRIM30A, potentially increasing its ligase activity. Similarly, agents that affect intracellular calcium levels or proteasome function (e.g., Ionomycin, Thapsigargin, Epoxomicin) could create a cellular context that necessitates enhanced TRIM30A-mediated ubiquitination. Compounds that target key signaling nodes such as PI3K, mTOR, or MAPK (e.g., LY294002, Rapamycin, SB203580, U0126) may indirectly influence TRIM30A activity by perturbing the network of proteins that TRIM30A interacts with or modifies. These indirect activators, through their specific actions on cellular signaling or protein modification pathways, ultimately contribute to the functional enhancement of TRIM30A.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which enhances PKA activity. PKA can then phosphorylate various substrates including those within pathways that TRIM30A may be involved, leading to the functional enhancement of TRIM30A. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin elevates intracellular calcium levels, which may activate calcium-dependent proteins that interact with or regulate TRIM30A, thus indirectly enhancing its functional activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits SERCA pumps, increasing cytosolic calcium levels. Elevated calcium can activate pathways that possibly engage TRIM30A, enhancing its activity indirectly by influencing associated calcium-dependent processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates PKC, which participates in signaling pathways. PKC activation could lead to phosphorylation of proteins within the TRIM30A pathway, thereby enhancing the activity of TRIM30A. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
As a proteasome inhibitor, Epoxomicin increases the pool of ubiquitinated proteins, potentially enhancing TRIM30A activity due to a greater need for ubiquitin ligase activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid inhibits protein phosphatases PP1 and PP2A, leading to increased protein phosphorylation. This could enhance TRIM30A activity by increasing the pool of phosphorylated substrates requiring ubiquitination by TRIM30A. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
By inhibiting protein phosphatases, Calyculin A induces hyperphosphorylation, which can increase substrate availability for TRIM30A and potentially enhance its ubiquitin ligase activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, leading to alterations in signaling pathways that may intersect with TRIM30A's function, thus indirectly enhancing TRIM30A's ubiquitin ligase activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, can lead to cellular changes that may enhance the ubiquitination processes in which TRIM30A is involved, thereby indirectly enhancing its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, which may lead to the enhancement of TRIM30A activity on proteins that are part of the p38 MAPK signaling pathway, thereby increasing its functional activity. | ||||||