TREM-3 Inhibitors
TREM-3 inhibitors are compounds that function by modulating the activity of the Triggering Receptor Expressed on Myeloid cells-3 (TREM-3), a receptor that plays a critical role in immune response regulation, particularly in myeloid cells like macrophages and neutrophils. TREM-3, a member of the immunoglobulin superfamily, is predominantly found on these cells and is involved in amplifying the signaling pathways initiated by pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs). The activity of TREM-3 contributes to the release of various pro-inflammatory cytokines and chemokines, which are essential for mounting a rapid immune response to pathogens or foreign substances. However, TREM-3 overactivation can lead to excessive inflammatory responses. Therefore, inhibitors of TREM-3 serve as key molecules in biochemical research to study the regulation of immune cell signaling and inflammation control mechanisms at the molecular level.
Structurally, TREM-3 inhibitors are typically small molecules, peptides, or even monoclonal antibodies that are designed to either block the ligand-binding site of the receptor or interfere with downstream signaling pathways associated with its activation. These inhibitors can prevent the phosphorylation of the receptor-associated adaptor protein, DNAX-activating protein of 12kDa (DAP12), which is necessary for initiating the intracellular signaling cascade. By blocking this pathway, researchers can explore how modulation of TREM-3 affects immune responses at the cellular level, including changes in cytokine production, immune cell migration, and phagocytic activity. Understanding these biochemical interactions and the specific role of TREM-3 in immune cell function provides valuable insight into its role in broader immunological processes, particularly the balance between activation and resolution of inflammation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Danoprevir | 850876-88-9 | sc-364480 sc-364480A | 5 mg 50 mg | $320.00 $1950.00 | ||
Resatorvid may inhibit TREM-3 expression by potentially acting as a selective inhibitor of TLR8 (Toll-like receptor 8). Inhibition of TLR8 signaling could lead to downstream effects on TREM-3 expression, as TLR8 activation has been linked to the modulation of TREM-3 expression and function. | ||||||
Resatorvid | 243984-11-4 | sc-476758 | 5 mg | $360.00 | ||
TAK-242 may inhibit TREM-3 expression by potentially acting as a selective inhibitor of TLR4 (Toll-like receptor 4) signaling. Inhibition of TLR4 signaling could lead to downstream effects on TREM-3 expression, as TLR4 activation has been linked to the modulation of TREM-3 expression and function. | ||||||
BX 795 | 702675-74-9 | sc-281689 sc-281689A sc-281689C sc-281689B sc-281689D sc-281689E | 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg | $219.00 $273.00 $331.00 $495.00 $882.00 $1489.00 | 5 | |
BX795 may inhibit TREM-3 expression by potentially acting as an inhibitor of TANK-binding kinase 1 (TBK1). Inhibition of TBK1 activity could lead to downstream effects on TREM-3 expression, as TBK1 has been linked to the regulation of TREM-3 expression and function through its involvement in various signaling pathways. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 may inhibit TREM-3 expression by potentially acting as an inhibitor of nuclear factor kappa B (NF-κB) activation. Inhibition of NF-κB activation could lead to downstream effects on TREM-3 expression, as NF-κB has been implicated in the regulation of TREM-3 expression and function through its involvement in inflammatory signaling pathways. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
JSH-23 may inhibit TREM-3 expression by potentially acting as an inhibitor of nuclear factor kappa B (NF-κB) activation. Inhibition of NF-κB activation could lead to downstream effects on TREM-3 expression, as NF-κB has been implicated in the regulation of TREM-3 expression and function through its involvement in inflammatory signaling pathways. | ||||||
LCL-161 | 1005342-46-0 | sc-507541 | 10 mg | $360.00 | ||
VTX-2337 may inhibit TREM-3 expression by potentially acting as a selective toll-like receptor 8 (TLR8) agonist. Modulation of TLR8 signaling could lead to downstream effects on TREM-3 expression, as TLR8 activation has been linked to the modulation of TREM-3 expression and function. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $306.00 | 1 | |
BMS-345541 may inhibit TREM-3 expression by potentially acting as an inhibitor of nuclear factor kappa B (NF-κB) activation. Inhibition of NF-κB activation could lead to downstream effects on TREM-3 expression, as NF-κB has been implicated in the regulation of TREM-3 expression and function through its involvement in inflammatory signaling pathways. | ||||||
[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone | 873225-46-8 | sc-503387 | 10 mg | $430.00 | ||
IMD 0354 may inhibit TREM-3 expression by potentially actingas an inhibitor of nuclear factor kappa B (NF-κB) activation. Inhibition of NF-κB activation could lead to downstream effects on TREM-3 expression, as NF-κB has been implicated in the regulation of TREM-3 expression and function through its involvement in inflammatory signaling pathways. | ||||||