Molecular structure of LCL-161, CAS Number: 1005342-46-0
LCL-161 (CAS 1005342-46-0)
CAS Number:
1005342-46-0
Molecular Weight:
500.6
Molecular Formula:
C26H33FN4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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LCL-161 (CAS 1005342-46-0) References
- The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock. | West, AC., et al. 2016. Oncogenesis. 5: e216. PMID: 27043662
- SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages. | Campbell, GR., et al. 2020. Cell Death Dis. 11: 590. PMID: 32719312
- Smac-mimetics reduce numbers and viability of human osteoclasts. | Moen, IN., et al. 2021. Cell Death Discov. 7: 36. PMID: 33608503
- Next Generation Therapeutics for the Treatment of Myelofibrosis. | Tremblay, D. and Mascarenhas, J. 2021. Cells. 10: PMID: 33925695
- CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells. | Campbell, GR., et al. 2021. Theranostics. 11: 9009-9021. PMID: 34522224
- The combination of TRAIL and the Smac mimetic LCL-161 induces an irreversible phenotypic change of MCF-7 breast cancer cells. | Granqvist, V., et al. 2022. Exp Mol Pathol. 125: 104739. PMID: 35007560
- Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader. | Nakano, N., et al. 2022. J Biochem. 171: 631-640. PMID: 35211741
- Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP. | Holmgren, C., et al. 2022. Curr Issues Mol Biol. 44: 4803-4821. PMID: 36286042
- Celastrol inhibits necroptosis by attenuating the RIPK1/RIPK3/MLKL pathway and confers protection against acute pancreatitis in mice. | Liang, QQ., et al. 2023. Int Immunopharmacol. 117: 109974. PMID: 37012867
- Natural Flavonoids Quercetin and Kaempferol Targeting G2/M Cell Cycle-Related Genes and Synergize with Smac Mimetic LCL-161 to Induce Necroptosis in Cholangiocarcinoma Cells. | Lomphithak, T., et al. 2023. Nutrients. 15: PMID: 37513508
Inhibitor of:
BIRC8, c-IAP 1, c-IAP2, EG627009, GP2, Idax, LPPR4, ML-IAP, PACS-1a, Stat5a, TREM-3, TRUNDD, and XIAP.Activator of:
caspase-9, FLIPL, HVEM, MLKL, NKG2-D, and RIP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LCL-161, 10 mg | sc-507541 | 10 mg | $360.00 |